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Gene Review:

Efna2 - ephrin A2

Rattus norvegicus

Rodger, J. et al., Symonds, A.C. et al., Lai, K.O. et al.

Rodger, Symonds, Springbett, Shen, Bartlett, Rakoczy, Beazley, Dunlop,

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High impact information on Efna2

More importantly, both EphA4 and EphA7, as well as ephrin-A2, were localized at the neuromuscular junction (NMJ) of adult muscle [1].
Following unilateral optic nerve section in adult PVG hooded rat, the axon guidance cue ephrin-A2 is up-regulated in caudal but not rostral superior colliculus (SC) and the EphA5 receptor is down-regulated in axotomised retinal ganglion cells (RGCs) [2].
Up-regulation of ephrin-A2 in caudal, but not rostral, SC suggests the enhancement of developmental positional information as a result of injury [2].
Reinnervation of the superior colliculus delays down-regulation of ephrin A2 in neonatal rat [3].

Other interactions of Efna2

Results are compared to normal animals in which tectal ephrin-A2 and retinal EphA5 are expressed, respectively, as shallow ascending rostro-caudal and naso-temporal gradients [2].

Analytical, diagnostic and therapeutic context of Efna2

Our results show that innervation but not denervation triggers increased ephrin A2 expression after a brachial lesion [3].
Here we use immunohistochemistry to examine expression of the guidance cue ephrin A2 following a brachial lesion [3].

References

Expression of Eph receptors in skeletal muscle and their localization at the neuromuscular junction. Lai, K.O., Ip, F.C., Cheung, J., Fu, A.K., Ip, N.Y. Mol. Cell. Neurosci. (2001) [Pubmed]
Eph/ephrin expression in the adult rat visual system following localized retinal lesions: localized and transneuronal up-regulation in the retina and superior colliculus. Rodger, J., Symonds, A.C., Springbett, J., Shen, W.Y., Bartlett, C.A., Rakoczy, P.E., Beazley, L.D., Dunlop, S.A. Eur. J. Neurosci. (2005) [Pubmed]
Reinnervation of the superior colliculus delays down-regulation of ephrin A2 in neonatal rat. Symonds, A.C., Rodger, J., Tan, M.M., Dunlop, S.A., Beazley, L.D., Harvey, A.R. Exp. Neurol. (2001) [Pubmed]

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EFNA2	Bos taurus
efna2a	Danio rerio
LOC100332852	Danio rerio
EFNA2	Gallus gallus
EFNA2	Homo sapiens
LOC721231	Macaca mulatta
Efna2	Mus musculus
EFNA2	Pan troglodytes
efna2	Xenopus (Silurana) tropicalis

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