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Gene Review

EFNA2  -  ephrin-A2

Homo sapiens

Synonyms: ELF-1, EPH-related receptor tyrosine kinase ligand 6, EPLG6, Ephrin-A2, HEK7 ligand, ...
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Disease relevance of EFNA2

  • Methods: Female nude mice injected intraperitoneally with HeyA8 ovarian cancer cells were treated with either docetaxel alone or in combination with anti-angiogenic agents (AEE788-dual VEGFR and EGFR antagonist or EA5-monoclonal antibody against ephrin A2) [1].

High impact information on EFNA2

  • Cleavage of ephrin-A2 by the ADAM10 membrane metalloprotease enables contact repulsion between Eph- and ephrin-expressing cells [2].
  • We now show that activation of ephrin-A2 or ephrin-A5 by one of their receptors, ephA3, results in a beta 1-integrin-dependent increased adhesion of ephrin-A-expressing cells to laminin [3].
  • Tyrosine phosphorylation of this protein is not seen after stimulating ephrin-A2-expressing cells with basic fibroblast growth factor, epidermal growth factor, insulin growth factor, or fetal calf serum containing a large set of different growth factors [3].
  • A repulsive mechanism involving opposing gradients of the EphA3 receptor on retinal axons and its ligands, ephrin-A2 and ephrin-A5, in the tectum influences topographic mapping of the retinotectal projection [4].
  • Recent reports have implicated Mek4, a member of the Eph (also named class V) family of tyrosine kinase receptors (RTKs), and two ligands, RAGS and ELF-1, in this process [5].

Biological context of EFNA2


Anatomical context of EFNA2


Associations of EFNA2 with chemical compounds

  • Ephrin-A5 and Ephrin-A2 are ligands for the EphA subfamily of Eph receptor tyrosine kinases, which are expressed in overlapping gradients in the posterior part of the tectum [12].

Other interactions of EFNA2

  • While these results suggest that Ephrin-A5 and Ephrin-A2 form part of the posterior repulsive guidance activity, they do not elucidate whether they are necessary components [12].

Analytical, diagnostic and therapeutic context of EFNA2


  1. Circulating Cell-Free DNA: A Novel Biomarker for Response to Therapy in Ovarian Carcinoma. Kamat, A.A., Bischoff, F.Z., Dang, D., Baldwin, M.F., Han, L.Y., Lin, Y.G., Merritt, W.M., Landen, C.N., Lu, C., Gershenson, D.M., Simpson, J.L., Sood, A.K. Cancer Biol. Ther. (2006) [Pubmed]
  2. Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. Janes, P.W., Saha, N., Barton, W.A., Kolev, M.V., Wimmer-Kleikamp, S.H., Nievergall, E., Blobel, C.P., Himanen, J.P., Lackmann, M., Nikolov, D.B. Cell (2005) [Pubmed]
  3. An ephrin-A-dependent signaling pathway controls integrin function and is linked to the tyrosine phosphorylation of a 120-kDa protein. Huai, J., Drescher, U. J. Biol. Chem. (2001) [Pubmed]
  4. Expression and tyrosine phosphorylation of Eph receptors suggest multiple mechanisms in patterning of the visual system. Connor, R.J., Menzel, P., Pasquale, E.B. Dev. Biol. (1998) [Pubmed]
  5. The receptor tyrosine kinase QEK5 mRNA is expressed in a gradient within the neural retina and the tectum. Kenny, D., Bronner-Fraser, M., Marcelle, C. Dev. Biol. (1995) [Pubmed]
  6. Cloning, chromosal mapping, and tissue expression of the gene encoding the human Eph-family kinase ligand ephrin-A2. Aasheim, H.C., Pedeutour, F., Grosgeorge, J., Logtenberg, T. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  7. Rac1-mediated endocytosis during ephrin-A2- and semaphorin 3A-induced growth cone collapse. Jurney, W.M., Gallo, G., Letourneau, P.C., McLoon, S.C. J. Neurosci. (2002) [Pubmed]
  8. Expression of ephrin-A2 in the superior colliculus and EphA5 in the retina following optic nerve section in adult rat. Rodger, J., Lindsey, K.A., Leaver, S.G., King, C.E., Dunlop, S.A., Beazley, L.D. Eur. J. Neurosci. (2001) [Pubmed]
  9. Response of retinal ganglion cell axons to striped linear gradients of repellent guidance molecules. Rosentreter, S.M., Davenport, R.W., Löschinger, J., Huf, J., Jung, J., Bonhoeffer, F. J. Neurobiol. (1998) [Pubmed]
  10. High EphA3 expressing ophthalmic trigeminal sensory axons are sensitive to ephrin-A5-Fc: implications for lobe specific axon guidance. Jayasena, C.S., Flood, W.D., Koblar, S.A. Neuroscience (2005) [Pubmed]
  11. Expression of EphA4, ephrin-A2 and ephrin-A5 during axon outgrowth to the hindlimb indicates potential roles in pathfinding. Eberhart, J., Swartz, M., Koblar, S.A., Pasquale, E.B., Tanaka, H., Krull, C.E. Dev. Neurosci. (2000) [Pubmed]
  12. Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro. Ciossek, T., Monschau, B., Kremoser, C., Löschinger, J., Lang, S., Müller, B.K., Bonhoeffer, F., Drescher, U. Eur. J. Neurosci. (1998) [Pubmed]
  13. Graded expression of EphA3 in the retina and ephrin-A2 in the superior colliculus during initial development of coarse topography in the wallaby retinocollicular projection. Stubbs, J., Palmer, A., Vidovic, M., Marotte, L.R. Eur. J. Neurosci. (2000) [Pubmed]
  14. Graded ephrin-A2 expression in the developing hamster superior colliculus. Lukehurst, S.S., King, C.E., Beazley, L.D., Tay, D.K., So, K.F., Rodger, J. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2006) [Pubmed]
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