High impact information on HTH

• HTH is a member of a small gene family in Arabidopsis and encodes an enzyme related to a group of FAD-containing oxidoreductases that have been described in several other species [1].
• Isolation and characterization of the Arabidopsis organ fusion gene HOTHEAD [1].
• The ACE/HTH gene is also expressed in root epidermal cells which do not form a polyester membrane on the exterior surface, thereby making it possible that the end products of the pathway, alpha-,omega-dicarboxylic FAs, are generally required for the cross-linking that ensures the integrity of the outer epidermal cell wall [2].
• Plant genetics: Increased outcrossing in hothead mutants [3].
• Here I describe a 'distributed genome' model that also explains their results, in which mutant hth DNA is restored by homologous sequences present in the genome itself [4].

Biological context of HTH

• Here we show that Arabidopsis plants homozygous for recessive mutant alleles of the organ fusion gene HOTHEAD (HTH) can inherit allele-specific DNA sequence information that was not present in the chromosomal genome of their parents but was present in previous generations [5].

Analytical, diagnostic and therapeutic context of HTH

• Here, we describe the molecular cloning and characterization of HOTHEAD (HTH), a gene required to limit cellular interactions between contacting epidermal cells during floral development [1].

References