Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Ihh - Indian hedgehog

Rattus norvegicus

Wu, S. et al., Wang, D. et al.

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High impact information on Ihh

Lastly, AY 9944 decreased the expression of Ihh in the metatarsal growth plate [1].
Based on this evidence, we hypothesized that cholesterol, by modifying the activity of Ihh (another of the Hedgehog family proteins) in the growth plate, regulates longitudinal bone growth [1].
We conclude that reduced cholesterol synthesis in the growth plate, possibly by altering the normal activity of Ihh, results in suppressed longitudinal bone growth and growth plate chondrogenesis [1].
Regulated expression and activity of Glvr-1 by extracellular phosphate and parathyroid hormone-related protein was restricted to an early stage of CFK2 differentiation, as evidenced by expression of type II collagen, proteoglycan, and Ihh [2].

References

Role of cholesterol in the regulation of growth plate chondrogenesis and longitudinal bone growth. Wu, S., De Luca, F. J. Biol. Chem. (2004) [Pubmed]
Alterations in the sensing and transport of phosphate and calcium by differentiating chondrocytes. Wang, D., Canaff, L., Davidson, D., Corluka, A., Liu, H., Hendy, G.N., Henderson, J.E. J. Biol. Chem. (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

IHH	Bos taurus
IHH	Canis lupus familiaris
ihha	Danio rerio
ihhb	Danio rerio
IHH	Gallus gallus
IHH	Homo sapiens
IHH	Macaca mulatta
Ihh	Mus musculus
IHH	Pan troglodytes
ihh	Xenopus (Silurana) tropicalis

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