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Chemical Compound Review

AY-9944     N-[(2-chlorophenyl)methyl]-1- [4-[[(2...

Synonyms: AG-K-26304, SureCN7920921, SureCN7920925, AC1L1TMS, LS-56442, ...
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Disease relevance of AY-9944


High impact information on AY-9944


Chemical compound and disease context of AY-9944


Biological context of AY-9944

  • Rat embryos explanted at gestation day 10 and cultured for 48 h in the presence of the Delta7 reductase inhibitor AY 9944 were used as a model to discriminate between the beneficial effect of supplementation with cholesterol and the deleterious effect of supplementation with 7-dehydrocholesterol [13].
  • Compared to LH-induced resumption of meiosis in follicles, that induced by AY-9944 was much delayed [14].
  • Thus, the resumption of meiosis induced by added MAS [Biol. Reprod. 61 (1999) 1362, Biol. Reprod. 64 (2001) 418] or presumed endogenous MAS accumulation by AY-9944, resulted in oocyte maturation with remarkably slower kinetics than observed with LH stimulation [15].
  • Effects of drugs on cholesterol esterification in normal and Niemann-Pick type C fibroblasts: AY-9944, other cationic amphiphilic drugs and DMSO [16].
  • Our study suggests that the effect of AY-9944 on lung lipid metabolism is more detrimental in OAP-exposed rats than the expected benefit of AY-9944's simultaneous reduction in adrenal cortical activity [17].

Anatomical context of AY-9944


Associations of AY-9944 with other chemical compounds


Gene context of AY-9944


Analytical, diagnostic and therapeutic context of AY-9944

  • An animal model for this disease has been obtained from the offspring of pregnant rats treated with "distal" inhibitors of delta7-dehydrocholesterol reductase, AY-9944 or BM15766 [28].


  1. Niemann-Pick disease experimental model: sphingomyelinase reduction induced by AY-9944. Sakuragawa, N., Sakuragaw, M., Kuwabara, T., Pentchev, P.G., Barranger, J.A., Brady, R.O. Science (1977) [Pubmed]
  2. Role of cholesterol in the regulation of growth plate chondrogenesis and longitudinal bone growth. Wu, S., De Luca, F. J. Biol. Chem. (2004) [Pubmed]
  3. Restoration of immune response by a cationic amphiphilic drug (AY 9944) in vitro: a new approach To chemotherapy against human immunodeficiency virus type 1. Achour, A., Landureau, J.C., Salerno-Concalves, R., Mazière, J.C., Zagury, D. Antimicrob. Agents Chemother. (1998) [Pubmed]
  4. Brain sterols in the AY-9944 rat model of atypical absence seizures. Cortez, M.A., Cunnane, S.C., Snead, O.C. Epilepsia (2002) [Pubmed]
  5. Cholesterol prevents the teratogenic action of AY 9944: importance of the timing of cholesterol supplementation to rats. Barbu, V., Roux, C., Lambert, D., Dupuis, R., Gardette, J., Maziere, J.C., Maziere, C., Elefant, E., Polonovski, J. J. Nutr. (1988) [Pubmed]
  6. Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue distribution, expression, chromosomal localization, and regulation of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz syndrome-related protein. Bae, S.H., Lee, J.N., Fitzky, B.U., Seong, J., Paik, Y.K. J. Biol. Chem. (1999) [Pubmed]
  7. Lovastatin exacerbates atypical absence seizures with only minimal effects on brain sterols. Serbanescu, I., Ryan, M.A., Shukla, R., Cortez, M.A., Snead, O.C., Cunnane, S.C. J. Lipid Res. (2004) [Pubmed]
  8. Aberrant pathways in the late stages of cholesterol biosynthesis in the rat. Origin and metabolic fate of unsaturated sterols relevant to the Smith-Lemli-Opitz syndrome. Ruan, B., Tsai, J., Wilson, W.K., Schroepfer, G.J. J. Lipid Res. (2000) [Pubmed]
  9. Serotonin depletion attenuates AY-9944-mediated atypical absence seizures. Bercovici, E., Cortez, M.A., Wang, X., Snead, O.C. Epilepsia (2006) [Pubmed]
  10. A chronic model of atypical absence seizures: studies of developmental and gender sensitivity. Persad, V., Cortez, M.A., Snead, O.C. Epilepsy Res. (2002) [Pubmed]
  11. Effects of trans-clomiphene in combination with AY-9944 on rat CNS morphology and biochemistry. Ramsey, R.B., Fischer, V.W. Acta Neuropathol. (1976) [Pubmed]
  12. Pharmacological models of generalized absence seizures in rodents. Snead, O.C. J. Neural Transm. Suppl. (1992) [Pubmed]
  13. Oxidized derivatives of 7-dehydrocholesterol induce growth retardation in cultured rat embryos: a model for antenatal growth retardation in the Smith-Lemli-Opitz syndrome. Gaoua, W., Chevy, F., Roux, C., Wolf, C. J. Lipid Res. (1999) [Pubmed]
  14. Meiosis-activating sterol synthesis in rat preovulatory follicle: is it involved in resumption of meiosis? Cao, X., Pomerantz, S.H., Popliker, M., Tsafriri, A. Biol. Reprod. (2004) [Pubmed]
  15. Is meiosis activating sterol (MAS) an obligatory mediator of meiotic resumption in mammals. Tsafriri, A., Cao, X., Vaknin, K.M., Popliker, M. Mol. Cell. Endocrinol. (2002) [Pubmed]
  16. Effects of drugs on cholesterol esterification in normal and Niemann-Pick type C fibroblasts: AY-9944, other cationic amphiphilic drugs and DMSO. Yoshikawa, H. Brain Dev. (1991) [Pubmed]
  17. Increased susceptibility to pulmonary oxygen toxicity after cholesterol biosynthesis inhibition. Brodsky, J.B. Aviation, space, and environmental medicine. (1975) [Pubmed]
  18. Effect of AY 9944 and chlorpromazine on Concanavalin A-induced stimulation of human lymphocytes. Barbu, V., Mazière, J.C., Maindrault, F., Mazière, C., Rampini, C., Roux, C., Polonovski, J. Biochem. Pharmacol. (1987) [Pubmed]
  19. Teratogenic effect of AY 9944 in rats: importance of the day of administration and maternal plasma cholesterol level. Barbu, V., Roux, C., Dupuis, R., Gardette, J., Maziere, J.C. Proc. Soc. Exp. Biol. Med. (1984) [Pubmed]
  20. Effect of hypocholesterolemic agents on central nervous system cholesterol biosynthesis. II. AY-9944 and AY-9944 plus zuclomiphene. Ramsey, R.B., Fredericks, M. Biochem. Pharmacol. (1977) [Pubmed]
  21. Estrogen-stimulated progesterone synthesis in rabbit corpora lutea in the presence of an inhibitor of cholesterol biosynthesis (AY-9944). Fuller, G.B., Markaverich, B.M., Hobson, W.C. Biol. Reprod. (1978) [Pubmed]
  22. Abnormal sterol metabolism in patients with Conradi-Hünermann-Happle syndrome and sporadic lethal chondrodysplasia punctata. Kelley, R.I., Wilcox, W.G., Smith, M., Kratz, L.E., Moser, A., Rimoin, D.S. Am. J. Med. Genet. (1999) [Pubmed]
  23. Relationships between cholesterogenesis, microsomal sterols and HMG-CoA reductase in the perfused rat liver. Goh, E.H. Lipids (1980) [Pubmed]
  24. Smith-Lemli-Opitz syndrome produced in rats with AY 9944 treated by intravenous injection of lipoprotein cholesterol. Chambers, C.M., McLean, M.P., Ness, G.C. Am. J. Med. Genet. (1997) [Pubmed]
  25. Refractory atypical absence seizures in rat: a two hit model. Serbanescu, I., Cortez, M.A., McKerlie, C., Snead, O.C. Epilepsy Res. (2004) [Pubmed]
  26. Reduction of acid sphingomyelinase activity in human fibroblasts induced by AY-9944 and other cationic amphiphilic drugs. Yoshida, Y., Arimoto, K., Sato, M., Sakuragawa, N., Arima, M., Satoyoshi, E. J. Biochem. (1985) [Pubmed]
  27. Evaluation of a nonisotopic technique for studies of in vivo cholesterol metabolism in mini-pigs using inhibition of 7-dehydrocholesterol reductase by AY 9944. Kaiser, W., Stocker, K. Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. (1978) [Pubmed]
  28. Normal and inhibited cholesterol synthesis in the cultured rat embryo. Llirbat, B., Wolf, C., Chevy, F., Citadelle, D., Bereziat, G., Roux, C. J. Lipid Res. (1997) [Pubmed]
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