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MeSH Review

Metatarsal Bones

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Disease relevance of Metatarsal Bones


High impact information on Metatarsal Bones


Chemical compound and disease context of Metatarsal Bones


Biological context of Metatarsal Bones


Anatomical context of Metatarsal Bones


Associations of Metatarsal Bones with chemical compounds

  • Lastly, AY 9944 decreased the expression of Ihh in the metatarsal growth plate [22].
  • Metatarsal density correlated with estradiol levels only in the dancers (r = 0.34, P less than 0.02) [25].
  • OBJECTIVE: We studied the relationship between vasoconstrictor changes in foot arteries (pedal, metatarsal, and digital arteries) and autonomic neuropathy in diabetic patients to estimate the degrees of sympathetic dysfunction [26].
  • RESULTS: DH Pressure Relief Walkers reduced plantar pressures significantly better than other commercially available treatments for ulcers under the first metatarsal, second through fifth metatarsals, and great toe (P < 0.05) [27].
  • Fetal mouse metatarsals were cultured for up to 10 d with dexamethasone (Dex; 10(-6) m) and/or IGF-I and GH (both at 100 ng/ml) [28].

Gene context of Metatarsal Bones

  • Interactions between FGFR3- and PTHrP-receptor-mediated signals during endochondral ossification were examined with embryonic metatarsal bones maintained in culture under defined conditions [29].
  • Previously, we have shown that PTHrP also acts downstream of transforming growth factor beta (TGFbeta) in a common signaling cascade to regulate hypertrophic differentiation in embryonic mouse metatarsal organ cultures [30].
  • The cultured mutant metatarsal bones failed to response to TGF-beta1, while the hypertrophic differentiation was largely inhibited by Sonic hedgehog (Shh) [31].
  • Furthermore, BMP-7 could still inhibit terminal chondrocyte differentiation in the metatarsals of PTHrP-deficient (PTHrP-/-) mouse embryos [32].
  • In addition, precocious expression of Bmp7 in the metatarsal epidermis of the Silkie mutant or treatment of the metatarsus with ectopic BMP7 protein results in feather development from scale forming integument [33].

Analytical, diagnostic and therapeutic context of Metatarsal Bones


  1. Childhood-onset osteoarthritis, tall stature, and sensorineural hearing loss associated with Arg75-Cys mutation in procollagen type II gene (COL2A1). Löppönen, T., Körkkö, J., Lundan, T., Seppänen, U., Ignatius, J., Kääriäinen, H. Arthritis Rheum. (2004) [Pubmed]
  2. Macrophage colony-stimulating factor restores bone resorption in op/op bone in vitro in conjunction with parathyroid hormone or 1,25-dihydroxyvitamin D3. Morohashi, T., Corboz, V.A., Fleisch, H., Cecchini, M.G., Felix, R. J. Bone Miner. Res. (1994) [Pubmed]
  3. The metatarsal cytochemical bioassay of parathyroid hormone: validation, specificity, and application to the study of pseudohypoparathyroidism type I. Bradbeer, J.N., Dunham, J., Fischer, J.A., Nagant de Deuxchaisnes, C., Loveridge, N. J. Clin. Endocrinol. Metab. (1988) [Pubmed]
  4. Treatment of osteomyelitis and septic arthritis with cefazolin. Fass, R.J. Antimicrob. Agents Chemother. (1978) [Pubmed]
  5. Cross-sectional geometry of the human forefoot. Griffin, N.L., Richmond, B.G. Bone (2005) [Pubmed]
  6. FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway. Sahni, M., Ambrosetti, D.C., Mansukhani, A., Gertner, R., Levy, D., Basilico, C. Genes Dev. (1999) [Pubmed]
  7. The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes. MacLean, H.E., Guo, J., Knight, M.C., Zhang, P., Cobrinik, D., Kronenberg, H.M. J. Clin. Invest. (2004) [Pubmed]
  8. TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. Yang, X., Chen, L., Xu, X., Li, C., Huang, C., Deng, C.X. J. Cell Biol. (2001) [Pubmed]
  9. A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation. Jiménez, M.J., Balbín, M., Alvarez, J., Komori, T., Bianco, P., Holmbeck, K., Birkedal-Hansen, H., López, J.M., López-Otín, C. J. Cell Biol. (2001) [Pubmed]
  10. Effects on fracture healing of an antagonist of the vitamin K cycle. Dodds, R.A., Catterall, A., Bitensky, L., Chayen, J. Calcif. Tissue Int. (1984) [Pubmed]
  11. Differing calcium sensitivities of human cerebral and digital arteries, human metatarsal veins, and rat aorta. Iwanov, V., Moulds, R.F. British journal of clinical pharmacology. (1991) [Pubmed]
  12. Postoperative analgesia after peripheral nerve block for podiatric surgery: clinical efficacy and chemical stability of lidocaine alone versus lidocaine plus clonidine. Reinhart, D.J., Wang, W., Stagg, K.S., Walker, K.G., Bailey, P.L., Walker, E.B., Zaugg, S.E. Anesth. Analg. (1996) [Pubmed]
  13. The effects of citric acid on phytate-phosphorus utilization in young chicks and pigs. Boling, S.D., Webel, D.M., Mavromichalis, I., Parsons, C.M., Baker, D.H. J. Anim. Sci. (2000) [Pubmed]
  14. Do hormonal (stress) and vascular (ischaemia) factors contribute to reflex muscle atrophy induced by chronic nociceptive stimulation in rats? Hník, P., Holas, M., Payne, R., Kraus, M., Erdösová, R., Jakoubek, B. Physiologia Bohemoslovaca. (1977) [Pubmed]
  15. Development of cardiovascular function in the horse fetus. Giussani, D.A., Forhead, A.J., Fowden, A.L. J. Physiol. (Lond.) (2005) [Pubmed]
  16. Human foot bones from Klasies River main site, South Africa. Rightmire, G.P., Deacon, H.J., Schwartz, J.H., Tattersall, I. J. Hum. Evol. (2006) [Pubmed]
  17. Abnormalities in fracture healing induced by vitamin B6-deficiency in rats. Dodds, R.A., Catterall, A., Bitensky, L., Chayen, J. Bone (1986) [Pubmed]
  18. Recombinant human extracellular matrix protein 1 inhibits alkaline phosphatase activity and mineralization of mouse embryonic metatarsals in vitro. Deckers, M.M., Smits, P., Karperien, M., Ni, J., Tylzanowski, P., Feng, P., Parmelee, D., Zhang, J., Bouffard, E., Gentz, R., Löwik, C.W., Merregaert, J. Bone (2001) [Pubmed]
  19. Locally produced estrogen promotes fetal rat metatarsal bone growth; an effect mediated through increased chondrocyte proliferation and decreased apoptosis. Chagin, A.S., Chrysis, D., Takigawa, M., Ritzen, E.M., Sävendahl, L. J. Endocrinol. (2006) [Pubmed]
  20. A retinoic acid-binding protein from chick embryo skin. Sani, B.P., Hill, D.L. Cancer Res. (1976) [Pubmed]
  21. Differential effects of C- and N-terminal substance P metabolites on the release of amino acid neurotransmitters from the spinal cord: potential role in nociception. Skilling, S.R., Smullin, D.H., Larson, A.A. J. Neurosci. (1990) [Pubmed]
  22. Role of cholesterol in the regulation of growth plate chondrogenesis and longitudinal bone growth. Wu, S., De Luca, F. J. Biol. Chem. (2004) [Pubmed]
  23. Expression of calcitonin receptors during osteoclast differentiation in mouse metatarsals. Taylor, L.M., Tertinegg, I., Okuda, A., Heersche, J.N. J. Bone Miner. Res. (1989) [Pubmed]
  24. Expression of matrix proteins during the development of mineralized tissues. Sommer, B., Bickel, M., Hofstetter, W., Wetterwald, A. Bone (1996) [Pubmed]
  25. Lack of bone accretion and amenorrhea: evidence for a relative osteopenia in weight-bearing bones. Warren, M.P., Brooks-Gunn, J., Fox, R.P., Lancelot, C., Newman, D., Hamilton, W.G. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  26. Sympathetic function test of vasoconstrictor changes in foot arteries in diabetic patients. Takahashi, T., Nishizawa, Y., Emoto, M., Kawagishi, T., Matsumoto, N., Ishimura, E., Inaba, M., Okuno, Y., Shimada, H., Morii, H. Diabetes Care (1998) [Pubmed]
  27. Reducing dynamic foot pressures in high-risk diabetic subjects with foot ulcerations. A comparison of treatments. Lavery, L.A., Vela, S.A., Lavery, D.C., Quebedeaux, T.L. Diabetes Care (1996) [Pubmed]
  28. Insulin-like growth factor-I augments chondrocyte hypertrophy and reverses glucocorticoid-mediated growth retardation in fetal mice metatarsal cultures. Mushtaq, T., Bijman, P., Ahmed, S.F., Farquharson, C. Endocrinology (2004) [Pubmed]
  29. A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia. Chen, L., Li, C., Qiao, W., Xu, X., Deng, C. Hum. Mol. Genet. (2001) [Pubmed]
  30. TGFbeta2 mediates the effects of hedgehog on hypertrophic differentiation and PTHrP expression. Alvarez, J., Sohn, P., Zeng, X., Doetschman, T., Robbins, D.J., Serra, R. Development (2002) [Pubmed]
  31. Smad4 is required for the normal organization of the cartilage growth plate. Zhang, J., Tan, X., Li, W., Wang, Y., Wang, J., Cheng, X., Yang, X. Dev. Biol. (2005) [Pubmed]
  32. Inhibition of terminal chondrocyte differentiation by bone morphogenetic protein 7 (OP-1) in vitro depends on the periarticular region but is independent of parathyroid hormone-related peptide. Haaijman, A., Karperien, M., Lanske, B., Hendriks, J., Löwik, C.W., Bronckers, A.L., Burger, E.H. Bone (1999) [Pubmed]
  33. Bmp7 mediates early signaling events during induction of chick epidermal organs. Harris, M.P., Linkhart, B.L., Fallon, J.F. Dev. Dyn. (2004) [Pubmed]
  34. Results of modified Robert Jones operation for clawed hallux. M'Bamali, E.I. The British journal of surgery. (1975) [Pubmed]
  35. Lactose intolerance associated with fractures of weight-bearing bones in Finnish women aged 38-57 years. Honkanen, R., Kröger, H., Alhava, E., Turpeinen, P., Tuppurainen, M., Saarikoski, S. Bone (1997) [Pubmed]
  36. Bone non-union after osteotomy in patients treated with methotrexate. Gerster, J.C., Bossy, R., Dudler, J. J. Rheumatol. (1999) [Pubmed]
  37. Developmental and TGF-beta-mediated regulation of Ank mRNA expression in cartilage and bone. Sohn, P., Crowley, M., Slattery, E., Serra, R. Osteoarthr. Cartil. (2002) [Pubmed]
  38. Effects of acetylpromazine on the hemodynamics of the equine metatarsal artery, as determined by two-dimensional real-time and pulsed Doppler ultrasonography. Walker, M., Geiser, D. Am. J. Vet. Res. (1986) [Pubmed]
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