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Gene Review:

OPR2 - 12-oxophytodienoate reductase 2

Arabidopsis thaliana

Synonyms: 12-OXOPHYTODIENOATE REDUCTASE 2, ARABIDOPSIS 12-OXOPHYTODIENOATE REDUCTASE 2, ATOPR2, F28O16.6, F28O16_6

Sobajima, H. et al., Mezzari, M.P. et al., Biesgen, C. et al., Schaller, F. et al.

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Disease relevance of OPR2

The three enzymes were expressed in a functional form in Escherichia coli, and OPR2 was additionally expressed in insect cell cultures and overexpressed in A. thaliana [1].

High impact information on OPR2

Genes selected for this study were AtGSTF2, AtGSTU1, AtGSTU24, and two isoforms of 12-oxophytodienoate reductase (OPR1 and OPR2) [2].
Results indicate that OPR2 is involved in plant metabolism of TNT (11-fold induction), and in oxidative stress when exposed to AOC (7-fold), MOC (9-fold), and RDX (2-fold) [2].

Biological context of OPR2

Nucleotide sequence analysis indicated that the cDNA encodes an homologue of the yeast Old Yellow Enzyme. The deduced amino acid sequence was very similar to the sequences of 12-oxophytodienoic acid reductases (OPR) 1 and 2 from Arabidopsis thaliana(AtOPR1 and AtOPR2) and OPR1 from tomato ( Lycopersicon esculentum) (LeOPR1) [3].

Associations of OPR2 with chemical compounds

The genes of two closely related 12-oxophytodienoic acid reductases (EC 1.3.1.42), OPR1 and OPR2, were identified on a 7079-bp-long genomic fragment from Arabidopsis thaliana (L.) Heynh [4].

References

12-Oxophytodienoate reductase 3 (OPR3) is the isoenzyme involved in jasmonate biosynthesis. Schaller, F., Biesgen, C., Müssig, C., Altmann, T., Weiler, E.W. Planta (2000) [Pubmed]
Gene expression and microscopic analysis of Arabidopsis exposed to chloroacetanilide herbicides and explosive compounds. A phytoremediation approach. Mezzari, M.P., Walters, K., Jelínkova, M., Shih, M.C., Just, C.L., Schnoor, J.L. Plant Physiol. (2005) [Pubmed]
Cloning and characterization of a jasmonic acid-responsive gene encoding 12-oxophytodienoic acid reductase in suspension-cultured rice cells. Sobajima, H., Takeda, M., Sugimori, M., Kobashi, N., Kiribuchi, K., Cho, E.M., Akimoto, C., Yamaguchi, T., Minami, E., Shibuya, N., Schaller, F., Weiler, E.W., Yoshihara, T., Nishida, H., Nojiri, H., Omori, T., Nishiyama, M., Yamane, H. Planta (2003) [Pubmed]
Structure and regulation of OPR1 and OPR2, two closely related genes encoding 12-oxophytodienoic acid-10,11-reductases from Arabidopsis thaliana. Biesgen, C., Weiler, E.W. Planta (1999) [Pubmed]

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OPR1	Arabidopsis thaliana
AGOS_AGR329C	Ashbya gossypii ATCC 10895
KLLA0A09075g	Kluyveromyces lactis NRRL Y-1140
MGG_08297	Magnaporthe oryzae 70-15
NCU04452	Neurospora crassa OR74A
Os06g0215600	Oryza sativa Japonica Group
Os06g0215900	Oryza sativa Japonica Group
Os02g0559400	Oryza sativa Japonica Group
Os06g0216300	Oryza sativa Japonica Group
Os06g0215500	Oryza sativa Japonica Group
Os06g0216200	Oryza sativa Japonica Group
OYE3	Saccharomyces cerevisiae S288c
OYE2	Saccharomyces cerevisiae S288c
SPAC5H10.04	Schizosaccharomyces pombe 972h-
SPAC5H10.10	Schizosaccharomyces pombe 972h-

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