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Chemical Compound Review

Harness     2-chloro-N-(ethoxymethyl)-N- (2-ethyl-6...

Synonyms: Nevirex, Acenit, Azetochlor, Erunit, acetochlor, ...
 
 
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Disease relevance of Erunit

 

High impact information on Erunit

 

Chemical compound and disease context of Erunit

  • Ecological toxicity of acetochlor and excessive urea, in both their single and joint effects, on earthworm Esisenia foelide was thus studied using the soil-culture method [8].
 

Biological context of Erunit

  • Thus, with 12 pesticides that mode of action judgments can be made, 11 disrupt thyroid-pituitary homeostasis only; no chemical is mutagenic only; and acetochlor may have both antithyroid and some mutagenic activity [9].
  • Rats treated with 2000 mg/kg acetochlor had normal testicular and epididymal pathology and normal sperm numbers and sperm motility at the critical third sampling period [10].
  • Daphnia fecundity declined with exposure to toxaphene, and daphnid growth rates were reduced by acetochlor exposure [11].
  • Simple first-order kinetics (Model 1) adequately described acetochlor persistence in Hamilton clay loam soil (Humic Hapludull, Illuvial Spadic) at the high application rate, but overestimated it at the low application rate [12].
  • The tumours were not life-threatening, they did not metastasize, and no DNA damage was induced in the nasal cells of rats maintained on a diet containing the MTD of acetochlor for either 1 or 18 weeks (comet assay) [2].
 

Anatomical context of Erunit

 

Associations of Erunit with other chemical compounds

 

Gene context of Erunit

  • This change in TR ratios is recapitulated with 10nM acetochlor in R. catesbeiana tadpole brains during prometamorphosis, a period in which THs are endogenously produced [18].
  • Interaction of acetochlor with estrogen receptor in the rat uterus. Acetochlor--possible endocrine modulator [19]?
 

Analytical, diagnostic and therapeutic context of Erunit

References

  1. The fate of herbicide acetochlor and its toxicity to Eisenia fetida under laboratory conditions. Xiao, N., Jing, B., Ge, F., Liu, X. Chemosphere (2006) [Pubmed]
  2. Evaluation of the potential carcinogenicity and genetic toxicity to humans of the herbicide acetochlor. Ashby, J., Kier, L., Wilson, A.G., Green, T., Lefevre, P.A., Tinwell, H., Willis, G.A., Heydens, W.F., Clapp, M.J. Human & experimental toxicology. (1996) [Pubmed]
  3. Idiopathic atrial fibrillation in a champion Standardbred racehorse. Stewart, G.A., Fulton, L.J., McKellar, C.D. Aust. Vet. J. (1990) [Pubmed]
  4. Isolation and characterization of a pseudomonas oleovorans degrading the chloroacetamide herbicide acetochlor. Xu, J., Qiu, X., Dai, J., Cao, H., Yang, M., Zhang, J., Xu, M. Biodegradation (2006) [Pubmed]
  5. Gene expression and microscopic analysis of Arabidopsis exposed to chloroacetanilide herbicides and explosive compounds. A phytoremediation approach. Mezzari, M.P., Walters, K., Jelínkova, M., Shih, M.C., Just, C.L., Schnoor, J.L. Plant Physiol. (2005) [Pubmed]
  6. Identification of ionic chloroacetanilide-herbicide metabolites in surface water and groundwater by HPLC/MS using negative ion spray. Ferrer, I., Thurman, E.M., Barceló, D. Anal. Chem. (1997) [Pubmed]
  7. Exposure to the herbicide acetochlor alters thyroid hormone-dependent gene expression and metamorphosis in Xenopus Laevis. Crump, D., Werry, K., Veldhoen, N., Van Aggelen, G., Helbing, C.C. Environ. Health Perspect. (2002) [Pubmed]
  8. Single and joint effects of acetochlor and urea on earthworm Esisenia foelide populations in phaiozem. Xiao, H., Zhou, Q.X., Liang, J.D. Environmental geochemistry and health. (2004) [Pubmed]
  9. Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. Hurley, P.M. Environ. Health Perspect. (1998) [Pubmed]
  10. Evaluation of the mutagenicity of acetochlor to male rat germ cells. Ashby, J., Tinwell, H., Lefevre, P.A., Williams, J., Kier, L., Adler, I.D., Clapp, M.J. Mutat. Res. (1997) [Pubmed]
  11. Effects of common-use pesticides on developmental and reproductive processes in Daphnia. Kashian, D.R., Dodson, S.I. Toxicology and industrial health. (2002) [Pubmed]
  12. Field dissipation of acetochlor in two New Zealand soils at two application rates. Ma, Q., Rahman, A., Holland, P.T., James, T.K., McNaughton, D.E. J. Environ. Qual. (2004) [Pubmed]
  13. Carbon fibre reinforced plastic applied to prosthetics and orthotics. Nelham, R.L. Journal of biomedical engineering. (1981) [Pubmed]
  14. Aquatic herbicides and herbicide contaminants: In vitro cytotoxicity and cell-cycle analysis. Freeman, J.L., Rayburn, A.L. Environ. Toxicol. (2006) [Pubmed]
  15. The acetochlor registration partnership: prospective ground water monitoring program. Newcombe, A.C., Gustafson, D.I., Fuhrman, J.D., van Wesenbeeck, I.J., Simmons, N.D., Klein, A.J., Travis, K.Z., Harradine, K.J. J. Environ. Qual. (2005) [Pubmed]
  16. The role of reactive oxygen species in the herbicide acetochlor-induced DNA damage on Bufo raddei tadpole liver. Liu, Y., Zhang, Y., Liu, J., Huang, D. Aquat. Toxicol. (2006) [Pubmed]
  17. Environmental distribution of acetochlor, atrazine, chlorpyrifos, and propisochlor under field conditions. Konda, L.N., Pásztor, Z. J. Agric. Food Chem. (2001) [Pubmed]
  18. Evaluation of the effect of acetochlor on thyroid hormone receptor gene expression in the brain and behavior of Rana catesbeiana tadpoles. Helbing, C.C., Ovaska, K., Ji, L. Aquat. Toxicol. (2006) [Pubmed]
  19. Interaction of acetochlor with estrogen receptor in the rat uterus. Acetochlor--possible endocrine modulator? Rollerová, E., Gáspárová, Z., Wsólová, L., Urbancíková, M. Gen. Physiol. Biophys. (2000) [Pubmed]
  20. Organoclay formulations of acetochlor: effect of high salt concentration. El-Nahhal, Y., Lagaly, G., Rabinovitz, O. J. Agric. Food Chem. (2005) [Pubmed]
  21. Determination of acetochlor in technical and formulated products by capillary gas chromatography: PVM 5:1999. Kahn, B.B., Tomkins, D.F. Journal of AOAC International. (2001) [Pubmed]
  22. Plantar pressure reduction in an incremental weight-bearing system. Flynn, T.W., Canavan, P.K., Cavanagh, P.R., Chiang, J.H. Physical therapy. (1997) [Pubmed]
 
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