The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • OMIM
  • SNPedia
  • UniProt
  • Ensembl
  • HGNC

Table of contents

About

Terms

 

Gene Review: 

L3MBTL3  -  l(3)mbt-like 3 (Drosophila)

Homo sapiens

Synonyms: H-l(3)mbt-like protein 3, KIAA1798, L(3)mbt-like protein 3, Lethal(3)malignant brain tumor-like protein 3, MBT-1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of L3MBTL3

  • The human MBT-1 gene is located on chromosome 6q23, a region frequently deleted in leukemia cells, and shows a transient expression spike in response to maturation-inducing stimuli in myeloid leukemia cells [1].
 

High impact information on L3MBTL3

  • Together, we conclude that MBT-1 specifically regulates the maturational advancement of myeloid progenitor cells during transitions between two developmental stages [1].
  • This results in the accumulation of immature myeloid progenitors and hence, a marked decrease of mature myeloid blood cells, causing the MBT-1(-/-) mice to die of anemia during a late embryonic stage [1].
  • We also show that MBT-1 appears to influence myelopoiesis by transiently enhancing p57(KIP2) expression levels [1].
  • Role of L3MBTL3 N183T polymorphism in progression of IgA nephropathy (IgAN) [2].
 

Analytical, diagnostic and therapeutic context of L3MBTL3

  • SDS-PAGE (Blose 1981) of mung bean tubulin has shown it to consist of two major subunits (MBT1 and MBT2) and a minor subunit (MBT3) [3].
  • Monoclonal antibodies to mammalian alpha and beta-tubulin subunits (MCA-T alpha and MCA-T beta, respectively) and Western blot analysis clearly demonstrated a cross-reactivity of MCA-T alpha with MBT2, MBT3, CT2 and CT3, while MCA-T beta showed cross-reactivity with MBT1 and CT1 [3].

References

  1. Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1. Arai, S., Miyazaki, T. EMBO J. (2005) [Pubmed]
  2. Role of L3MBTL3 N183T polymorphism in progression of IgA nephropathy (IgAN). Saito, N., Narita, I., Goto, S., Kondo, D., Sato, F., Yao, F.F., Ogawa, A., Tsubata, Y., Sakatsume, M., Ueno, M., Gejyo, F. Nephrology (Carlton, Vic.) (2006) [Pubmed]
  3. Some biochemical properties of higher plant tubulins. Mizuno, K., Perkin, J., Sek, F., Gunning, B. Cell Biol. Int. Rep. (1985) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities