Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

PARP10 - poly (ADP-ribose) polymerase family,...

Homo sapiens

Synonyms: ADP-ribosyltransferase diphtheria toxin-like 10, ARTD10, FLJ14464, PARP-10

Yu, M. et al., Chou, H.Y. et al.

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High impact information on PARP10

The PARP activity of PARP10 depends on phosphorylation by CDK2-cyclin E in vitro [1].
These results suggest that PARP10 functions in cell proliferation and may serve as a marker for proliferating cells [1].
Overexpression of PARP10 results in loss of cell viability, although down-expression by short hairpin RNA leads to delayed G1 progression and concomitant cell death [1].
Functionally, PARP-10 inhibits c-Myc- and E1A-mediated cotransformation of rat embryo fibroblasts, a function that is independent of PARP activity but that depends on a functional NES [2].
PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation [2].

Biological context of PARP10

PARP-10 is localized to the nuclear and cytoplasmic compartments that is controlled at least in part by a Leu-rich nuclear export sequence (NES) [2].

References

CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10). Chou, H.Y., Chou, H.T., Lee, S.C. J. Biol. Chem. (2006) [Pubmed]
PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation. Yu, M., Schreek, S., Cerni, C., Schamberger, C., Lesniewicz, K., Poreba, E., Vervoorts, J., Walsemann, G., Grötzinger, J., Kremmer, E., Mehraein, Y., Mertsching, J., Kraft, R., Austen, M., Lüscher-Firzlaff, J., Lüscher, B. Oncogene (2005) [Pubmed]

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