High impact information on CGNL1

• Furthermore, in the liver and kidney, JACOP was also distributed along non-junctional actin filaments [1].
• Overexpression studies have revealed that JACOP was recruited to the junctional complex in epithelial cells and to cell-cell contacts and stress fibers in fibroblasts [1].
• Immunofluorescence staining showed that JACOP was concentrated in the junctional complex in various types of epithelial and endothelial cells [1].
• These findings suggest that JACOP is involved in anchoring the apical junctional complex, especially TJs, to actin-based cytoskeletons [1].
• Upon immunoelectron microscopy, JACOP was found to be localized to the undercoat of TJs in the liver, but in some tissues, its distribution was not restricted to TJs but extended to the area of adherens junctions [1].

References