The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GBP2  -  Gbp2p

Saccharomyces cerevisiae S288c

Synonyms: G-strand-binding protein 2, RAP1 localization factor 6, RLF6, Single-strand telomeric DNA-binding protein GBP2, YCL011C, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on GBP2

  • Consistent with these findings, Gbp2 and Hrb1 associate with actively transcribed genes throughout their entire lengths [1].
  • We also show that Gbp2 and Hrb1 interact with Ctk1, a kinase that phosphorylates the C-terminal domain of RNA polymerase II during transcription elongation [1].
  • In addition, expression of Chlamydomonas GBP1 restores perinuclear, punctate Rap1p localization in rlf6 mutant cells [2].
  • The functional complementation of a fungal gene by an algal gene suggests that Rlf6p and Gbp1p are members of a conserved class of single-stranded telomeric DNA-binding proteins that influence nuclear organization [2].
  • The protein is similar to the other two serine/arginine (SR)-type proteins in yeast, Gbp2 and Npl3 [3].

Biological context of GBP2

  • Although GBP2 is not essential for normal cell growth, overexpression of this gene is toxic and causes a nuclear retention of bulk poly(A)(+) RNA [4].
  • The second gene, GBP2 (G-strand Binding Protein), is an anonymous open reading frame from chromosome III [5].
  • The nuclear export of Gbp2 is always coupled to mRNA export and is dependent on continuous RNA polymerase II transcription and mRNA-export factors [4].
  • Moreover, the binding activity of Gbp2p to single-stranded TG(1-3) DNA appears to be associated with its ability to restore the telomere-lengthening phenotype in cdc13-1 cells [6].
  • These results indicate that Gbp2p is involved in modulating telomere length [6].

Associations of GBP2 with chemical compounds

  • Deletion of the genes encoding both of these proteins or disruption of two of the arginine/serine repeats each shifts the steady-state localization of Gbp2 to the cytoplasm [4].

Other interactions of GBP2


Analytical, diagnostic and therapeutic context of GBP2


WikiGenes - Universities