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Gene Review

HRB1  -  Hrb1p

Saccharomyces cerevisiae S288c

Synonyms: N2009, Protein HRB1, Protein TOM34, TOM34, YNL004W
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High impact information on HRB1

  • The export of a novel hnRNP-like protein, Hrb1p, which does not bind poly(A)+ RNA, however, is not affected by the lack of methylation [1].
  • Consistent with these findings, Gbp2 and Hrb1 associate with actively transcribed genes throughout their entire lengths [2].
  • We conclude that recruitment of the SR-like proteins Gbp2 and Hrb1 to mRNA occurs cotranscriptionally by means of association with the TREX complex and/or Ctk1 [2].
  • Hrb1 is nuclear at steady state and its import is mediated by the karyopherin Mtr10 [3].
  • Here, we present the characterization of Hrb1, a novel component of the transported ribonucleoprotein complex in Saccharomyces cerevisiae [3].

Biological context of HRB1

  • TOM34 codes for a putative RNA binding protein, and DOM34 defines a hypothetical polypeptide of 35 kDa, with no significant homology to known proteins [4].
  • Cellular localization and phosphorylation of Hrb1p is independent of Sky1p [5].
  • Furthermore, we demonstrate that Hrb1p and additional putative Sky1p substrates, identified by computational approach, are not involved in mediating the spermine tolerant phenotype of sky1Delta cells [5].

Analytical, diagnostic and therapeutic context of HRB1


  1. Arginine methylation facilitates the nuclear export of hnRNP proteins. Shen, E.C., Henry, M.F., Weiss, V.H., Valentini, S.R., Silver, P.A., Lee, M.S. Genes Dev. (1998) [Pubmed]
  2. Cotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex. Hurt, E., Luo, M.J., Röther, S., Reed, R., Strässer, K. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Differential export requirements for shuttling serine/arginine-type mRNA-binding proteins. Häcker, S., Krebber, H. J. Biol. Chem. (2004) [Pubmed]
  4. Organization of the centromeric region of chromosome XIV in Saccharomyces cerevisiae. Lalo, D., Stettler, S., Mariotte, S., Gendreau, E., Thuriaux, P. Yeast (1994) [Pubmed]
  5. Cellular localization and phosphorylation of Hrb1p is independent of Sky1p. Porat, Z., Erez, O., Kahana, C. Biochim. Biophys. Acta (2006) [Pubmed]
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