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Gene Review

MTR10  -  Mtr10p

Saccharomyces cerevisiae S288c

Synonyms: YOR160W, mRNA transport regulator MTR10
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High impact information on MTR10


Biological context of MTR10


Associations of MTR10 with chemical compounds

  • Moreover, using sucrose density gradient analysis, we provide evidence that the import receptor Mtr10p, but not the SR protein kinase Sky1p, is involved in the timely regulated release of Npl3p from polysome-associated mRNAs [6].

Physical interactions of MTR10

  • Purified Mtr10p forms a complex with Npl3p, an RNA-binding protein that shuttles in and out of the nucleus [2].

Other interactions of MTR10

  • Hrb1 is nuclear at steady state and its import is mediated by the karyopherin Mtr10 [7].
  • The redistribution of Npl3p is accompanied by its increased association with poly(A)+ RNA and decreased association with its import receptor, Mtr10p, in vivo [8].
  • MA utilizes Kap120p and Mtr10p import receptors while nuclear entry of NC involves the classical importin-alpha/beta (Kap60p/95p) pathway [9].


  1. Uncoupling of the hnRNP Npl3p from mRNAs during the stress-induced block in mRNA export. Krebber, H., Taura, T., Lee, M.S., Silver, P.A. Genes Dev. (1999) [Pubmed]
  2. Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Npl3p. Senger, B., Simos, G., Bischoff, F.R., Podtelejnikov, A., Mann, M., Hurt, E. EMBO J. (1998) [Pubmed]
  3. Multiple telophase arrest bypassed (tab) mutants alleviate the essential requirement for Cdc15 in exit from mitosis in S. cerevisiae. Shou, W., Deshaies, R.J. BMC Genet. (2002) [Pubmed]
  4. Conserved SR protein kinase functions in nuclear import and its action is counteracted by arginine methylation in Saccharomyces cerevisiae. Yun, C.Y., Fu, X.D. J. Cell Biol. (2000) [Pubmed]
  5. Biogenesis of yeast telomerase depends on the importin mtr10. Ferrezuelo, F., Steiner, B., Aldea, M., Futcher, B. Mol. Cell. Biol. (2002) [Pubmed]
  6. Yeast shuttling SR proteins Npl3p, Gbp2p, and Hrb1p are part of the translating mRNPs, and Npl3p can function as a translational repressor. Windgassen, M., Sturm, D., Cajigas, I.J., González, C.I., Seedorf, M., Bastians, H., Krebber, H. Mol. Cell. Biol. (2004) [Pubmed]
  7. Differential export requirements for shuttling serine/arginine-type mRNA-binding proteins. Häcker, S., Krebber, H. J. Biol. Chem. (2004) [Pubmed]
  8. Phosphorylation by Sky1p promotes Npl3p shuttling and mRNA dissociation. Gilbert, W., Siebel, C.W., Guthrie, C. RNA (2001) [Pubmed]
  9. Importin-beta family members mediate alpharetrovirus gag nuclear entry via interactions with matrix and nucleocapsid. Butterfield-Gerson, K.L., Scheifele, L.Z., Ryan, E.P., Hopper, A.K., Parent, L.J. J. Virol. (2006) [Pubmed]
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