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Gene Review:

TAF2 - Taf2p

Saccharomyces cerevisiae S288c

Synonyms: TAF150, TAFII-150, TBP-associated factor 150 kDa, TBP-associated factor 2, TSM-1, ...

Pham, T.A. et al., Metzger, D. et al., Ray, B.L. et al., Verrijzer, C.P. et al., Shen, W.C. et al.

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High impact information on TAF2

The deduced primary amino acid sequence of dTAFII150 reveals a striking similarity to the essential yeast gene, TSM-1 [1].
The percentage of the yeast genome dependent on each TAF ranges from 3% (TAF2) to 59-61% (TAF9) [2].
Our results indicate that both TAF-2 and the N-terminal transactivation region (TAF-1) are functional in yeast and contribute synergistically to the receptor's total activity [3].
We have also demonstrated that hER can activate transcription from chimaeric oestrogen-responsive GAL1 promoters in yeast, and shown that transcriptional activation was due to TAF-1, whereas TAF-2 showed little, if any, transcriptional activity on these promoters [4].
The DNA sequence of the first 4.4 kb distal to MAT reveals an open reading frame that we have identified as the essential gene, TSM1 [5].

Associations of TAF2 with chemical compounds

Furthermore, we show that in yeast the antagonistic effects of the antiestrogen nafoxidine arise from a modulation of the synergistic interactions of TAF-1 and TAF-2, and not simply from an inactivation of TAF-2 by antihormone [3].

References

Drosophila TAFII150: similarity to yeast gene TSM-1 and specific binding to core promoter DNA. Verrijzer, C.P., Yokomori, K., Chen, J.L., Tjian, R. Science (1994) [Pubmed]
Systematic analysis of essential yeast TAFs in genome-wide transcription and preinitiation complex assembly. Shen, W.C., Bhaumik, S.R., Causton, H.C., Simon, I., Zhu, X., Jennings, E.G., Wang, T.H., Young, R.A., Green, M.R. EMBO J. (2003) [Pubmed]
Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast. Pham, T.A., Hwung, Y.P., Santiso-Mere, D., McDonnell, D.P., O'Malley, B.W. Mol. Endocrinol. (1992) [Pubmed]
Promoter specificity of the two transcriptional activation functions of the human oestrogen receptor in yeast. Metzger, D., Losson, R., Bornert, J.M., Lemoine, Y., Chambon, P. Nucleic Acids Res. (1992) [Pubmed]
The TSM1 gene of Saccharomyces cerevisiae overlaps the MAT locus. Ray, B.L., White, C.I., Haber, J.E. Curr. Genet. (1991) [Pubmed]

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AGOS_AFR674C	Ashbya gossypii ATCC 10895
KLLA0C02189g	Kluyveromyces lactis NRRL Y-1140
MGG_03637	Magnaporthe oryzae 70-15
NCU02052	Neurospora crassa OR74A
taf2	Schizosaccharomyces pombe 972h-

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