The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

TAF9  -  TATA-binding protein-associated factor TAF9

Saccharomyces cerevisiae S288c

Synonyms: TAF17, TAFII-17, TAFII20, TBP-associated factor 17 kDa, TBP-associated factor 9, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on TAF9

  • In yeast, the TBP-associated factors (TAFs) Taf17, Taf60, and Taf61(68) resemble histones H3, H4, and H2B, respectively [1].
  • However, TAF17-depleted cells maintain Ace1-dependent activation, and they induce de novo activation by heat shock factor in a manner predominantly associated with the activator, not the core promoter [2].
  • The percentage of the yeast genome dependent on each TAF ranges from 3% (TAF2) to 59-61% (TAF9) [3].
  • Based on their predicted molecular weights, these genes have been designated TAF67, TAF61(68), TAF40, TAF23(25), TAF19(FUN81), and TAF17 [4].
  • A yeast taf17 mutant requires the Swi6 transcriptional activator for viability and shows defects in cell cycle-regulated transcription [5].

Biological context of TAF9

  • The cell cycle and transcriptional defects caused by taf17(slm7-1) are consistent with the role of TAF(II)s as modulators of transcriptional activation and may reflect a role for TAF17 in regulating activation by SBF and MBF [5].

Analytical, diagnostic and therapeutic context of TAF9

  • Complementation and allelism tests showed that SLM7 is allelic with the TAF17 gene, which encodes a histone-like component of the general transcription factor TFIID and the SAGA histone acetyltransferase complex [5].


  1. Histone-like TAFs are essential for transcription in vivo. Michel, B., Komarnitsky, P., Buratowski, S. Mol. Cell (1998) [Pubmed]
  2. The histone H3-like TAF is broadly required for transcription in yeast. Moqtaderi, Z., Keaveney, M., Struhl, K. Mol. Cell (1998) [Pubmed]
  3. Systematic analysis of essential yeast TAFs in genome-wide transcription and preinitiation complex assembly. Shen, W.C., Bhaumik, S.R., Causton, H.C., Simon, I., Zhu, X., Jennings, E.G., Wang, T.H., Young, R.A., Green, M.R. EMBO J. (2003) [Pubmed]
  4. Yeast homologues of higher eukaryotic TFIID subunits. Moqtaderi, Z., Yale, J.D., Struhl, K., Buratowski, S. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. A yeast taf17 mutant requires the Swi6 transcriptional activator for viability and shows defects in cell cycle-regulated transcription. Macpherson, N., Measday, V., Moore, L., Andrews, B. Genetics (2000) [Pubmed]
WikiGenes - Universities