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Gene Review

BUD8  -  Bud8p

Saccharomyces cerevisiae S288c

Synonyms: Bud site selection protein 8, L9638.3, YLR353W
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High impact information on BUD8

  • The importance of time of transcription in localization is supported by promoter-swap experiments: expression of Bud8p from the BUD9 promoter leads to its localization predominantly to the sites typical for Bud9p, and vice versa [1].
  • Here we provide evidence that Bud8p is delivered to the presumptive bud site (and thence to the distal pole of the bud) just before bud emergence, and that Bud9p is delivered to the bud side of the mother-bud neck (and thence to the proximal pole of the daughter cell) after activation of the mitotic exit network, just before cytokinesis [1].
  • Bud8p is highly concentrated at the distal pole of both YF and PH cells, where it directs initiation of cell division [2].
  • Bud5p with these additional N-terminal residues interacted with Bud8p, a potential bipolar landmark, suggesting that the N-terminal region is necessary for recognition of the spatial cues [3].
  • In response to glucose limitation, Bud8p was required for the localization of the incipient bud site marker Bud2p to the distal pole [4].

Biological context of BUD8

  • Asymmetrically localized Bud8p and Bud9p proteins control yeast cell polarity and development [2].
  • In particular, the Bud8p protein, which marks and directs bud emergence to the distal pole of diploid cells, was localized to the distal pole of haploid cells [4].

Anatomical context of BUD8

  • In Saccharomyces cerevisiae, Bud8p and Bud9p are homologous plasma membrane glycoproteins that appear to mark the distal and proximal cell poles, respectively, as potential sites for budding in the bipolar pattern [1].

Other interactions of BUD8

  • Rax1 is required for the localization of Bud8, the distal bipolar budding landmark [5].


  1. The role of cell cycle-regulated expression in the localization of spatial landmark proteins in yeast. Schenkman, L.R., Caruso, C., Pagé, N., Pringle, J.R. J. Cell Biol. (2002) [Pubmed]
  2. Asymmetrically localized Bud8p and Bud9p proteins control yeast cell polarity and development. Taheri, N., Köhler, T., Braus, G.H., Mösch, H.U. EMBO J. (2000) [Pubmed]
  3. Specific residues of the GDP/GTP exchange factor Bud5p are involved in establishment of the cell type-specific budding pattern in yeast. Kang, P.J., Lee, B., Park, H.O. J. Biol. Chem. (2004) [Pubmed]
  4. The roles of bud-site-selection proteins during haploid invasive growth in yeast. Cullen, P.J., Sprague, G.F. Mol. Biol. Cell (2002) [Pubmed]
  5. Rax1, a protein required for the establishment of the bipolar budding pattern in yeast. Fujita, A., Lord, M., Hiroko, T., Hiroko, F., Chen, T., Oka, C., Misumi, Y., Chant, J. Gene (2004) [Pubmed]
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