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Gene Review

CAR2  -  ornithine-oxo-acid transaminase

Saccharomyces cerevisiae S288c

Synonyms: CARGB, L9753.2, Ornithine aminotransferase, Ornithine--oxo-acid aminotransferase, YLR438W
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Disease relevance of CAR2


High impact information on CAR2

  • The correlation between ARG2 and CAR2 is found to change from positive to negative as the expression level of CPA2 increases [2].
  • To explore yeast as an expression system, we introduced a cDNA encoding human ornithine-delta-aminotransferase into an ornithine aminotransferase-deficient strain of Saccharomyces cerevisiae [3].
  • This histone deacetylase complex prevents the synthesis of the two arginine catabolic enzymes, arginase (CAR1) and ornithine transaminase (CAR2), as long as exogenous nitrogen is available [4].
  • We show that Rap1p binds upstream of CAR2 and plays a central role in its induced expression irrespective of whether the inducer is arginine or the allantoin pathway inducer analogue oxalurate (OXLU) [5].
  • The dominant activators of CAR2 transcription have been thought to be the ArgR and Mcm1 factors, which mediate arginine-dependent induction [5].

Biological context of CAR2

  • Within this negative region a ten base-pair sequence was detected that shows high homology to a sequence located within a negative control region of the CYC1 gene and some homology to the negative control elements of the S. cerevisiae CAR1 and CAR2 genes [6].

Associations of CAR2 with chemical compounds


  1. Escherichia coli and Saccharomyces cerevisiae acetylornithine aminotransferase: evolutionary relationship with ornithine aminotransferase. Heimberg, H., Boyen, A., Crabeel, M., Glansdorff, N. Gene (1990) [Pubmed]
  2. Genome-wide coexpression dynamics: theory and application. Li, K.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Expression and processing of human ornithine-delta-aminotransferase in Saccharomyces cerevisiae. Dougherty, K.M., Swanson, D.A., Brody, L.C., Valle, D. Hum. Mol. Genet. (1993) [Pubmed]
  4. In Saccharomyces cerevisiae, expression of arginine catabolic genes CAR1 and CAR2 in response to exogenous nitrogen availability is mediated by the Ume6 (CargRI)-Sin3 (CargRII)-Rpd3 (CargRIII) complex. Messenguy, F., Vierendeels, F., Scherens, B., Dubois, E. J. Bacteriol. (2000) [Pubmed]
  5. Synergistic operation of the CAR2 (Ornithine transaminase) promoter elements in Saccharomyces cerevisiae. Park, H.D., Scott, S., Rai, R., Dorrington, R., Cooper, T.G. J. Bacteriol. (1999) [Pubmed]
  6. Heme control region of the catalase T gene of the yeast Saccharomyces cerevisiae. Spevak, W., Hartig, A., Meindl, P., Ruis, H. Mol. Gen. Genet. (1986) [Pubmed]
  7. Molecular characterization of transposable-element-associated mutations that lead to constitutive L-ornithine aminotransferase expression in Saccharomyces cerevisiae. Degols, G., Jauniaux, J.C., Wiame, J.M. Eur. J. Biochem. (1987) [Pubmed]
  8. Functional analysis of the regulatory region adjacent to the cargB gene of Saccharomyces cerevisiae. Nucleotide sequence, gene fusion experiments and cis-dominant regulatory mutation analysis. Degols, G. Eur. J. Biochem. (1987) [Pubmed]
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