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Gene Review

SHR3  -  Shr3p

Saccharomyces cerevisiae S288c

Synonyms: D1022, Secretory component protein SHR3, YDL212W
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High impact information on SHR3


Biological context of SHR3


Anatomical context of SHR3

  • The SHR3 gene of Saccharomyces cerevisiae encodes an integral membrane component of the endoplasmic reticulum (ER) with four membrane-spanning segments and a hydrophilic, cytoplasmically oriented carboxyl-terminal domain [6].

Associations of SHR3 with chemical compounds

  • Thus, leflunomide is suggested to affect amino acid transport by interacting with Shr3 chaperon-like protein [7].

Regulatory relationships of SHR3

  • DNA sequencing analysis indicates that the MLF4 gene is identical to the SSH4 gene which suppresses the shr3 mutation [7].

Other interactions of SHR3

  • Pulse-chase experiments indicate that the Shr3p-Gap1p association is transient, a reflection of the exit of Gap1p from the ER [6].
  • Ssy1p requires the endoplasmic reticulum protein Shr3p, the amino acid permease-specific packaging chaperonin, to reach the PM, whereas Ptr3p does not [8].


  1. SHR3: a novel component of the secretory pathway specifically required for localization of amino acid permeases in yeast. Ljungdahl, P.O., Gimeno, C.J., Styles, C.A., Fink, G.R. Cell (1992) [Pubmed]
  2. Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER. Kota, J., Ljungdahl, P.O. J. Cell Biol. (2005) [Pubmed]
  3. Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro. Kuehn, M.J., Schekman, R., Ljungdahl, P.O. J. Cell Biol. (1996) [Pubmed]
  4. Salt stress-induced proline transporters and salt stress-repressed broad specificity amino acid permeases identified by suppression of a yeast amino acid permease-targeting mutant. Rentsch, D., Hirner, B., Schmelzer, E., Frommer, W.B. Plant Cell (1996) [Pubmed]
  5. Biogenesis of Candida albicans Can1 permease expressed in Saccharomyces cerevisiae. Matìjèková, A., Sychrová, H. FEBS Lett. (1997) [Pubmed]
  6. Shr3p mediates specific COPII coatomer-cargo interactions required for the packaging of amino acid permeases into ER-derived transport vesicles. Gilstring, C.F., Melin-Larsson, M., Ljungdahl, P.O. Mol. Biol. Cell (1999) [Pubmed]
  7. Molecular cloning of Saccharomyces cerevisiae MLF4/SSH4 gene which confers the immunosuppressant leflunomide resistance. Fujimura, H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  8. Ssy1p and Ptr3p are plasma membrane components of a yeast system that senses extracellular amino acids. Klasson, H., Fink, G.R., Ljungdahl, P.O. Mol. Cell. Biol. (1999) [Pubmed]
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