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Gene Review

MAK21  -  Mak21p

Saccharomyces cerevisiae S288c

Synonyms: D4237, Maintenance of killer protein 21, NOC1, Nucleolar complex protein 1, Ribosome biogenesis protein MAK21, ...
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High impact information on MAK21

  • Using a yeast genetic screen, we have identified Noc3p (nucleolar complex-associated protein) as a novel replication-initiation protein [1].
  • Here we show that Sir2 executes these functions as a component of a nucleolar complex designated RENT (regulator of nucleolar silencing and telophase exit) [2].
  • Instead, Paf1 loss altered poly(A) site utilization of primary target genes SDA1 and MAK21, resulting in increased abundance of 3'-extended mRNAs [3].
  • We cloned MAK21 using its map location and found that Mak21p is homologous to a human and mouse CAATT-binding protein and open reading frames in Schizosaccharomyces pombe and Caenorhabditis elegans [4].
  • Although the human protein regulates Hsp70 production, Mak21p is essential for growth and necessary for 60 S ribosomal subunit biogenesis. mak21-1 mutants have decreased levels of L-A coat protein and L-A double-stranded RNA [4].

Biological context of MAK21

  • Mak21p of Saccharomyces cerevisiae, a homolog of human CAATT-binding protein, is essential for 60 S ribosomal subunit biogenesis [4].
  • Overexpression of a conserved domain common to Noc1p and Noc3p is dominant-negative for cell growth, with a defect in nuclear 60S subunit transport, but no inhibition of pre-rRNA processing [5].
  • We designated the lesion responsible for the rRNA-processing defect rrp1 and showed that it is located on the right arm of chromosome IV either allelic to or tightly linked to mak21 [6].

Anatomical context of MAK21


  1. Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast. Zhang, Y., Yu, Z., Fu, X., Liang, C. Cell (2002) [Pubmed]
  2. Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Straight, A.F., Shou, W., Dowd, G.J., Turck, C.W., Deshaies, R.J., Johnson, A.D., Moazed, D. Cell (1999) [Pubmed]
  3. A posttranscriptional role for the yeast Paf1-RNA polymerase II complex is revealed by identification of primary targets. Penheiter, K.L., Washburn, T.M., Porter, S.E., Hoffman, M.G., Jaehning, J.A. Mol. Cell (2005) [Pubmed]
  4. Mak21p of Saccharomyces cerevisiae, a homolog of human CAATT-binding protein, is essential for 60 S ribosomal subunit biogenesis. Edskes, H.K., Ohtake, Y., Wickner, R.B. J. Biol. Chem. (1998) [Pubmed]
  5. Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Milkereit, P., Gadal, O., Podtelejnikov, A., Trumtel, S., Gas, N., Petfalski, E., Tollervey, D., Mann, M., Hurt, E., Tschochner, H. Cell (2001) [Pubmed]
  6. RRP1, a Saccharomyces cerevisiae gene affecting rRNA processing and production of mature ribosomal subunits. Fabian, G.R., Hopper, A.K. J. Bacteriol. (1987) [Pubmed]
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