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Gene Review

ALT2  -  alanine transaminase ALT2

Saccharomyces cerevisiae S288c

Synonyms: GPT, Glutamate pyruvate transaminase, Glutamic--alanine transaminase, Glutamic--pyruvic transaminase, YD9727.07C, ...
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High impact information on ALT2

  • When expressed in COS-1 cells, the cDNA causes a 5-7-fold increase of GPT activity in membrane fractions [1].
  • Several portions of the hamster GPT sequence constituting one-third of the protein have 60% or greater identity with yeast GPT, and one-half of the conserved sequence falls within the hydrophobic segments [1].
  • In the mice fed sake yeast, ethanol-induced increases in triglyceride (TG) and glutamate pyruvate transaminase (GPT) were significantly attenuated and hepatic steatosis was improved [2].


  1. Cloning, sequence, and expression of a cDNA encoding hamster UDP-GlcNAc:dolichol phosphate N-acetylglucosamine-1-phosphate transferase. Zhu, X.Y., Lehrman, M.A. J. Biol. Chem. (1990) [Pubmed]
  2. Sake yeast suppresses acute alcohol-induced liver injury in mice. Izu, H., Shobayashi, M., Manabe, Y., Goto, K., Iefuji, H. Biosci. Biotechnol. Biochem. (2006) [Pubmed]
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