Gene Review:
Gpt - glutamic pyruvic transaminase, soluble
Mus musculus
Synonyms:
1300007J06Rik, 2310022B03Rik, ALT, ALT1, Alanine aminotransferase 1, ...
Khandoga,
Kessler,
Hanschen,
Khandoga,
Burggraf,
Reichel,
Hamann,
Enders,
Krombach,
Satoh,
Nonaka,
Tada,
Fukumori,
Ogata,
Yamada,
Satoh,
Nagai,
Xu,
Wang,
Keshaw,
Xu,
Lam,
Cooper,
Erickson,
Bhattacharyya,
Hunter,
Heidenreich,
Cherrington,
Huff,
Huff,
Balog,
Rath,
Rajamohan,
Nelms,
Joslin,
Lu,
Reagan,
Lawton,
Yoshida,
Itoh,
Hayakawa,
Habuchi,
Inoue,
Chen,
Cao,
Cynshi,
Niki,
- Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver. Jadhao, S.B., Yang, R.Z., Lin, Q., Hu, H., Anania, F.A., Shuldiner, A.R., Gong, D.W., Jadaho, S.B. Hepatology (2004)
- cDNA cloning, expression, purification, distribution, and characterization of biologically active canine alanine aminotransferase-1. Rajamohan, F., Nelms, L., Joslin, D.L., Lu, B., Reagan, W.J., Lawton, M. Protein Expr. Purif. (2006)
- Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. Liu, Y., Binz, J., Numerick, M.J., Dennis, S., Luo, G., Desai, B., MacKenzie, K.I., Mansfield, T.A., Kliewer, S.A., Goodwin, B., Jones, S.A. J. Clin. Invest. (2003)
- Tacrine inhibits topoisomerases and DNA synthesis to cause mitochondrial DNA depletion and apoptosis in mouse liver. Mansouri, A., Haouzi, D., Descatoire, V., Demeilliers, C., Sutton, A., Vadrot, N., Fromenty, B., Feldmann, G., Pessayre, D., Berson, A. Hepatology (2003)
- Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice. Baribault, H., Penner, J., Iozzo, R.V., Wilson-Heiner, M. Genes Dev. (1994)
- Endothelial cells require STAT3 for protection against endotoxin-induced inflammation. Kano, A., Wolfgang, M.J., Gao, Q., Jacoby, J., Chai, G.X., Hansen, W., Iwamoto, Y., Pober, J.S., Flavell, R.A., Fu, X.Y. J. Exp. Med. (2003)
- The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. Xu, A., Wang, Y., Keshaw, H., Xu, L.Y., Lam, K.S., Cooper, G.J. J. Clin. Invest. (2003)
- Targeting urokinase-type plasminogen activator receptor on human glioblastoma tumors with diphtheria toxin fusion protein DTAT. Vallera, D.A., Li, C., Jin, N., Panoskaltsis-Mortari, A., Hall, W.A. J. Natl. Cancer Inst. (2002)
- CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver. Zwacka, R.M., Zhang, Y., Halldorson, J., Schlossberg, H., Dudus, L., Engelhardt, J.F. J. Clin. Invest. (1997)
- A sensitive molecular assay for mutagenesis in mammalian cells: reversion analysis in cells with a mutant shuttle vector gene integrated into chromosomal DNA. Gelbert, L.M., Davidson, R.L. Proc. Natl. Acad. Sci. U.S.A. (1988)
- Time dependence of the selective modulation of cisplatin-induced nephrotoxicity by WR2721 in the mouse. Treskes, M., Boven, E., Holwerda, U., Pinedo, H.M., van der Vijgh, W.J. Cancer Res. (1992)
- Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. Yang, S., Koteish, A., Lin, H., Huang, J., Roskams, T., Dawson, V., Diehl, A.M. Hepatology (2004)
- Inhibition of inflammatory liver injury by a monoclonal antibody against lymphocyte function-associated antigen-1. Tanaka, Y., Kobayashi, K., Takahashi, A., Arai, I., Higuchi, S., Otomo, S., Habu, S., Nishimura, T. J. Immunol. (1993)
- Disrupted galectin-3 causes non-alcoholic fatty liver disease in male mice. Nomoto, K., Tsuneyama, K., Abdel Aziz, H., Takahashi, H., Murai, Y., Cui, Z.G., Fujimoto, M., Kato, I., Hiraga, K., Hsu, D., Liu, F.T., Takano, Y. J. Pathol. (2006)
- Linkage between complement components 6 and 7 and glutamic pyruvate transaminase in the marsupial Monodelphis domestica. van Oorschot, R.A., Birmingham, V., Porter, P.A., Kammerer, C.M., VandeBerg, J.L. Biochem. Genet. (1993)
- Linomide prevents the lethal effect of anti-Fas antibody and reduces Fas-mediated ceramide production in mouse hepatocytes. Redondo, C., Flores, I., Gonzalez, A., Nagata, S., Carrera, A.C., Merida, I., Martinez-A, C. J. Clin. Invest. (1996)
- 16, 16 Dimethyl prostaglandin E2 prevents the development of fulminant hepatitis and blocks the induction of monocyte/macrophage procoagulant activity after murine hepatitis virus strain 3 infection. Abecassis, M., Falk, J.A., Makowka, L., Dindzans, V.J., Falk, R.E., Levy, G.A. J. Clin. Invest. (1987)
- Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis. Canbay, A., Higuchi, H., Bronk, S.F., Taniai, M., Sebo, T.J., Gores, G.J. Gastroenterology (2002)
- Inhibition of tumor necrosis factor alpha signaling by anti-tumor necrosis factor alpha antibodies and pentoxifylline is unable to prevent fumonisin hepatotoxicity in mice. He, Q., Sharma, R.P. Toxicon (2005)
- Transactivation of pancreas-specific gene sequences in somatic cell hybrids. Wu, K.J., Samuelson, L.C., Howard, G., Meisler, M.H., Darlington, G.J. Mol. Cell. Biol. (1991)
- Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and Fas-antibody-induced liver injury. Lawson, J.A., Fisher, M.A., Simmons, C.A., Farhood, A., Jaeschke, H. Hepatology (1998)
- Chromosomal location of soluble glutamic-pyruvic transaminase-1 (Gpt-1) in the mouse. Eicher, E.M., Womack, J.E. Biochem. Genet. (1977)
- Effects of N-nitrosofenfluramine, a component of Chinese dietary supplement for weight loss, on CD-1 mice. Satoh, K., Nonaka, R., Tada, Y., Fukumori, N., Ogata, A., Yamada, A., Satoh, T., Nagai, F. Arch. Toxicol. (2006)
- Physiological responses to a natural antioxidant flavonoid mixture, silymarin, in BALB/c mice: I induction of transforming growth factor beta1 and c-myc in liver with marginal effects on other genes. He, Q., Osuchowski, M.F., Johnson, V.J., Sharma, R.P. Planta Med. (2002)
- Effect of early handling of turkey poults on later responses to a dexamethasone-Escherichia coli challenge. 1. Production values and physiological response. Huff, G.R., Huff, W.E., Balog, J.M., Rath, N.C. Poult. Sci. (2001)
- Interleukin 1beta protects mice from Fas-mediated hepatocyte apoptosis and death. Takehara, T., Hayashi, N., Tatsumi, T., Kanto, T., Mita, E., Sasaki, Y., Kasahara, A., Hori, M. Gastroenterology (1999)
- Dibutyryl cyclic adenosine monophosphate protects mice against tumor necrosis factor-alpha-induced hepatocyte apoptosis accompanied by increased heat shock protein 70 expression. Takano, M., Arai, T., Mokuno, Y., Nishimura, H., Nimura, Y., Yoshikai, Y. Cell Stress Chaperones (1998)
- Lipid peroxidation in mice fed a choline-deficient diet as evaluated by total hydroxyoctadecadienoic acid. Yoshida, Y., Itoh, N., Hayakawa, M., Habuchi, Y., Inoue, R., Chen, Z.H., Cao, J., Cynshi, O., Niki, E. Nutrition (Burbank, Los Angeles County, Calif.) (2006)
- Albumin and alkaline phosphatase as factors involved in the regulation of tyrosine phenol-lyase activity. Meadows, G.G., Elmer, G.W. Res. Commun. Chem. Pathol. Pharmacol. (1978)
- Chromosomal locations of the mouse fatty acid oxidation genes Cpt1a, Cpt1b, Cpt2, Acadvl, and metabolically related Crat gene. Cox, K.B., Johnson, K.R., Wood, P.A. Mamm. Genome (1998)
- Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice. Yin, M., Wheeler, M.D., Kono, H., Bradford, B.U., Gallucci, R.M., Luster, M.I., Thurman, R.G. Gastroenterology (1999)
- Matrix metalloproteinase-9 promotes neutrophil and T cell recruitment and migration in the postischemic liver. Khandoga, A., Kessler, J.S., Hanschen, M., Khandoga, A.G., Burggraf, D., Reichel, C., Hamann, G.F., Enders, G., Krombach, F. J. Leukoc. Biol. (2006)
- Liver disease with altered bile acid transport in Niemann-Pick C mice on a high-fat, 1% cholesterol diet. Erickson, R.P., Bhattacharyya, A., Hunter, R.J., Heidenreich, R.A., Cherrington, N.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)
- Role of reactive oxygen intermediates in interleukin 10 release after cold liver ischemia and reperfusion in mice. Le Moine, O., Louis, H., Stordeur, P., Collet, J.M., Goldman, M., Devière, J. Gastroenterology (1997)
- Immunotherapy directed against alpha-fetoprotein results in autoimmune liver disease during liver regeneration in mice. Geissler, M., Mohr, L., Weth, R., Köhler, G., Grimm, C.F., Krohne, T.U., von Weizsäcker, F., Blum, H.E. Gastroenterology (2001)
- The role of hepatic type 1 plasminogen activator inhibitor (PAI-1) during murine hemorrhagic shock. Lagoa, C.E., Vodovotz, Y., Stolz, D.B., Lhuillier, F., McCloskey, C., Gallo, D., Yang, R., Ustinova, E., Fink, M.P., Billiar, T.R., Mars, W.M. Hepatology (2005)
- Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitis. Bonder, C.S., Ajuebor, M.N., Zbytnuik, L.D., Kubes, P., Swain, M.G. J. Immunol. (2004)
- A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases. Sova, P., Ren, X.W., Ni, S., Bernt, K.M., Mi, J., Kiviat, N., Lieber, A. Mol. Ther. (2004)