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Gene Review

SAN1  -  ubiquitin-protein ligase SAN1

Saccharomyces cerevisiae S288c

Synonyms: Protein SAN1, YD2943.02C, YDR143C
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High impact information on SAN1

  • We show here that one of the suppressor genes is the previously reported SAN1 gene; san1 mutations were originally identified as suppressors of a sir4 mutation, implicated in the chromatin-mediated transcriptional silencing of the two mating-type loci HML and HMR [1].
  • Our findings suggest that the San1 protein antagonizes the transcriptional activator function of the Cdc68 protein [1].
  • Consistent with the idea that San1 participates as an accessory factor to regulate silent chromatin, including the silent mating-type loci, microarray analysis defined a small but statistically significant role for San1 in transcription of several mating pheromone-responsive genes [2].
  • Sir Antagonist 1 (San1) is a ubiquitin ligase [2].
  • These suppressor mutations, which define at least three new genes, SAN1, SAN2 and SAN3, arose at the frequency expected for loss-of-function mutations following mutagenesis [3].

Biological context of SAN1


Regulatory relationships of SAN1

  • SAN1 may act posttranslationally to control the stability or activity of the SIR4 protein [3].
  • Mutations in Sir Antagonist 1 (SAN1) suppress defects in SIR4 and SPT16 in Saccharomyces cerevisiae [2].

Other interactions of SAN1

  • Consistent with this idea, mutant sir4 and spt16 proteins are unstable in SAN1 cells but are stabilized in san1Delta cells [2].


  1. The Saccharomyces cerevisiae Cdc68 transcription activator is antagonized by San1, a protein implicated in transcriptional silencing. Xu, Q., Johnston, G.C., Singer, R.A. Mol. Cell. Biol. (1993) [Pubmed]
  2. Sir Antagonist 1 (San1) is a ubiquitin ligase. Dasgupta, A., Ramsey, K.L., Smith, J.S., Auble, D.T. J. Biol. Chem. (2004) [Pubmed]
  3. Genetic and molecular characterization of suppressors of SIR4 mutations in Saccharomyces cerevisiae. Schnell, R., D'Ari, L., Foss, M., Goodman, D., Rine, J. Genetics (1989) [Pubmed]
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