Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

TCM62 - Tcm62p

Saccharomyces cerevisiae S288c

Synonyms: Mitochondrial chaperone TCM62, YBR0414, YBR044C

Dibrov, E. et al., Klanner, C. et al., Vander Heiden, M.G. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of TCM62

We demonstrate here crucial functions of Tcm62p under heat stress [1].

High impact information on TCM62

The finding that TCM62 and the analogous human prohibitin gene also inhibit mammalian cell death following growth factor withdrawal implicates mitochondrial chaperones as regulators of apoptosis [2].
The Tcm62p sequence is 17.3% identical to yeast hsp60, a molecular chaperone [3].
The Saccharomyces cerevisiae TCM62 gene encodes a chaperone necessary for the assembly of the mitochondrial succinate dehydrogenase (complex II) [3].
The complementing gene, TCM62 (also known as SCYBR044C), does not encode an SDH subunit and is not essential for cell viability [3].
These results suggest a more general chaperone function of Tcm62p in mitochondria [1].

Biological context of TCM62

The chaperonin-related protein Tcm62p ensures mitochondrial gene expression under heat stress [1].

References

The chaperonin-related protein Tcm62p ensures mitochondrial gene expression under heat stress. Klanner, C., Neupert, W., Langer, T. FEBS Lett. (2000) [Pubmed]
Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism. Vander Heiden, M.G., Choy, J.S., VanderWeele, D.J., Brace, J.L., Harris, M.H., Bauer, D.E., Prange, B., Kron, S.J., Thompson, C.B., Rudin, C.M. J. Biol. Chem. (2002) [Pubmed]
The Saccharomyces cerevisiae TCM62 gene encodes a chaperone necessary for the assembly of the mitochondrial succinate dehydrogenase (complex II). Dibrov, E., Fu, S., Lemire, B.D. J. Biol. Chem. (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AGOS_AER406C	Ashbya gossypii ATCC 10895
KLLA0B06732g	Kluyveromyces lactis NRRL Y-1140

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.