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Gene Review

NUT1  -  Nut1p

Saccharomyces cerevisiae S288c

Synonyms: G1876, MED5, Mediator complex subunit 5, Mediator of RNA polymerase II transcription subunit 5, Negative regulator of URS2 protein 1, ...
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High impact information on NUT1

  • Sequence alignment shows significant similarity of Nut1 to the GCN5-related N-acetyltransferase superfamily [1].
  • Three lines of evidence identify the Nut1 subunit of Mediator as responsible for the histone acetyltransferase (HAT) activity [1].
  • These results suggest that Nut1p, Nut2p, Sin4p, and Ccr4p define a group of proteins that negatively regulate transcription in a subtle manner which is revealed by artificial reporter genes [2].
  • Nuclear proteins Nut1p and Nut2p cooperate to negatively regulate a Swi4p-dependent lacZ reporter gene in Saccharomyces cerevisiae [2].
  • We found that NUT1 (open reading frame [ORF] YGL151w) is a nonessential gene, that NUT2 (ORF YPR168w) is essential, and that both Nut1p and Nut2p encode nuclear proteins [2].

Biological context of NUT1


Other interactions of NUT1

  • A second lower molecular size complex was also identified, termed Mediator core (Medc), which lacked pol II, Srb8-11, Rox3, Nut1, and the Rgrl module [4].


  1. Mediator-nucleosome interaction. Lorch, Y., Beve, J., Gustafsson, C.M., Myers, L.C., Kornberg, R.D. Mol. Cell (2000) [Pubmed]
  2. Nuclear proteins Nut1p and Nut2p cooperate to negatively regulate a Swi4p-dependent lacZ reporter gene in Saccharomyces cerevisiae. Tabtiang, R.K., Herskowitz, I. Mol. Cell. Biol. (1998) [Pubmed]
  3. The structural and functional role of Med5 in the yeast Mediator tail module. Béve, J., Hu, G.Z., Myers, L.C., Balciunas, D., Werngren, O., Hultenby, K., Wibom, R., Ronne, H., Gustafsson, C.M. J. Biol. Chem. (2005) [Pubmed]
  4. Yeast nuclear extract contains two major forms of RNA polymerase II mediator complexes. Liu, Y., Ranish, J.A., Aebersold, R., Hahn, S. J. Biol. Chem. (2001) [Pubmed]
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