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Gene Review

ROX3  -  Rox3p

Saccharomyces cerevisiae S288c

Synonyms: Hypoxic gene repressor protein 3, MED19, Mediator complex subunit 19, Mediator of RNA polymerase II transcription subunit 19, NUT3, ...
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High impact information on ROX3


Biological context of ROX3


Associations of ROX3 with chemical compounds


Regulatory relationships of ROX3

  • The ROX3 gene was identified during a hunt for mutants with increased expression of the heme-regulated CYC7 gene, which encodes the minor species of cytochrome c in the yeast Saccharomyces cerevisiae [4].

Other interactions of ROX3

  • A selection for high-copy suppressors of a ROX3 temperature-sensitive allele resulted in the isolation of RTS1, encoding a protein with homology to the B' regulatory subunit of protein phosphatase 2A0 [8].
  • Mutations in the ROX3 gene prevented CYC7 RNA accumulation during heat shock and osmotic stress [8].
  • We have identified two of these as the previously described GRR1/CAT80 and ROX3 genes [6].

Analytical, diagnostic and therapeutic context of ROX3

  • Yeast Rox3 protein, implicated by genetic evidence in both negative and positive transcriptional regulation, is identified as a mediator subunit by peptide sequence determination and is shown to copurify and co-immunoprecipitate with RNA polymerase II holoenzyme [9].


  1. The two isoenzymes for yeast NAD+-dependent glycerol 3-phosphate dehydrogenase encoded by GPD1 and GPD2 have distinct roles in osmoadaptation and redox regulation. Ansell, R., Granath, K., Hohmann, S., Thevelein, J.M., Adler, L. EMBO J. (1997) [Pubmed]
  2. SSN genes that affect transcriptional repression in Saccharomyces cerevisiae encode SIN4, ROX3, and SRB proteins associated with RNA polymerase II. Song, W., Treich, I., Qian, N., Kuchin, S., Carlson, M. Mol. Cell. Biol. (1996) [Pubmed]
  3. Phosphorylation of Ga14p at a single C-terminal residue is necessary for galactose-inducible transcription. Sadowski, I., Costa, C., Dhanawansa, R. Mol. Cell. Biol. (1996) [Pubmed]
  4. The ROX3 gene encodes an essential nuclear protein involved in CYC7 gene expression in Saccharomyces cerevisiae. Rosenblum-Vos, L.S., Rhodes, L., Evangelista, C.C., Boayke, K.A., Zitomer, R.S. Mol. Cell. Biol. (1991) [Pubmed]
  5. Yeast nuclear extract contains two major forms of RNA polymerase II mediator complexes. Liu, Y., Ranish, J.A., Aebersold, R., Hahn, S. J. Biol. Chem. (2001) [Pubmed]
  6. Regulation of nuclear genes encoding mitochondrial proteins in Saccharomyces cerevisiae. Brown, T.A., Evangelista, C., Trumpower, B.L. J. Bacteriol. (1995) [Pubmed]
  7. Activation of DNA replication in yeast by recruitment of the RNA polymerase II transcription complex. Stagljar, I., Hübscher, U., Barberis, A. Biol. Chem. (1999) [Pubmed]
  8. Rox3 and Rts1 function in the global stress response pathway in baker's yeast. Evangelista, C.C., Rodriguez Torres, A.M., Limbach, M.P., Zitomer, R.S. Genetics (1996) [Pubmed]
  9. Identification of Rox3 as a component of mediator and RNA polymerase II holoenzyme. Gustafsson, C.M., Myers, L.C., Li, Y., Redd, M.J., Lui, M., Erdjument-Bromage, H., Tempst, P., Kornberg, R.D. J. Biol. Chem. (1997) [Pubmed]
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