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Gene Review

COG2  -  Cog2p

Saccharomyces cerevisiae S288c

Synonyms: COG complex subunit 2, Component of oligomeric Golgi complex 2, Conserved oligomeric Golgi complex subunit 2, G6324, Protein SEC35, ...
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High impact information on COG2

  • We have identified three new proteins that associate with Sec35p and Sec34p in yeast cytosol [1].
  • Using a cell-free assay that measures distinct steps in vesicle transport from the ER to the Golgi, we find Sec35p is required for a vesicle docking stage catalyzed by Uso1p [2].
  • The cold-sensitive lethality that results from deleting SEC35 is suppressed by YPT1 or SLY1-20 [2].
  • These genetic and biochemical results suggest Sec35p acts with Uso1p to dock ER-derived vesicles to the Golgi complex [2].
  • SEC35 encodes a novel cytosolic protein of 32 kD, peripherally associated with membranes [2].

Biological context of COG2


Anatomical context of COG2


Other interactions of COG2

  • The sec31-sec35 mutants and additional alleles of previously identified sec and vacuolar protein sorting (vps) genes were isolated in a screen based on the detection of alpha-factor precursor in yeast colonies replicated to and lysed on nitrocellulose filters [5].
  • Sgf1p, a new component of the Sec34p/Sec35p complex [6].


  1. The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins. Suvorova, E.S., Duden, R., Lupashin, V.V. J. Cell Biol. (2002) [Pubmed]
  2. Sec35p, a novel peripheral membrane protein, is required for ER to Golgi vesicle docking. VanRheenen, S.M., Cao, X., Lupashin, V.V., Barlowe, C., Waters, M.G. J. Cell Biol. (1998) [Pubmed]
  3. Identification of Sec36p, Sec37p, and Sec38p: components of yeast complex that contains Sec34p and Sec35p. Ram, R.J., Li, B., Kaiser, C.A. Mol. Biol. Cell (2002) [Pubmed]
  4. Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p. VanRheenen, S.M., Cao, X., Sapperstein, S.K., Chiang, E.C., Lupashin, V.V., Barlowe, C., Waters, M.G. J. Cell Biol. (1999) [Pubmed]
  5. New mutants of Saccharomyces cerevisiae affected in the transport of proteins from the endoplasmic reticulum to the Golgi complex. Wuestehube, L.J., Duden, R., Eun, A., Hamamoto, S., Korn, P., Ram, R., Schekman, R. Genetics (1996) [Pubmed]
  6. Sgf1p, a new component of the Sec34p/Sec35p complex. Kim, D.W., Massey, T., Sacher, M., Pypaert, M., Ferro-Novick, S. Traffic (2001) [Pubmed]
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