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Gene Review

HAL5  -  Hal5p

Saccharomyces cerevisiae S288c

Synonyms: Halotolerance protein 5, J0531, Serine/threonine-protein kinase HAL5, YJL165C
 
 
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High impact information on HAL5

  • We have characterized two partially redundant genes from Saccharomyces cerevisiae, HAL4/SAT4 and HAL5, that encode homologous protein kinases implicated in the regulation of cation uptake [1].
  • This phenotype is suppressed by the TRK1 and HAL5 genes in high-copy number consistent with a defect in K(+) uptake mediated by the Trk system [2].
 

Associations of HAL5 with chemical compounds

  • Other nutrient transporters, such as Can1 (arginine permease), Fur4 (uracil permease), and Hxt1 (low-affinity glucose permease), are also destabilized in the hal4 hal5 mutant under low K+ conditions and, in the case of Can1, are stabilized by high K+ concentrations [3].
 

Biological context of HAL5

References

  1. A novel mechanism of ion homeostasis and salt tolerance in yeast: the Hal4 and Hal5 protein kinases modulate the Trk1-Trk2 potassium transporter. Mulet, J.M., Leube, M.P., Kron, S.J., Rios, G., Fink, G.R., Serrano, R. Mol. Cell. Biol. (1999) [Pubmed]
  2. A role for the non-phosphorylated form of yeast Snf1: tolerance to toxic cations and activation of potassium transport. Portillo, F., Mulet, J.M., Serrano, R. FEBS Lett. (2005) [Pubmed]
  3. Key role for intracellular K+ and protein kinases Sat4/Hal4 and Hal5 in the plasma membrane stabilization of yeast nutrient transporters. Pérez-Valle, J., Jenkins, H., Merchan, S., Montiel, V., Ramos, J., Sharma, S., Serrano, R., Yenush, L. Mol. Cell. Biol. (2007) [Pubmed]
  4. A novel pathway determining multidrug sensitivity in Schizosaccharomyces pombe. Thornton, G., Wilkinson, C.R., Toone, W.M., Jones, N. Genes Cells (2005) [Pubmed]
 
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