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Gene Review

NUP120  -  Nup120p

Saccharomyces cerevisiae S288c

Synonyms: Nuclear pore protein NUP120, Nucleoporin NUP120, RAT2, YKL057C, YKL313, ...
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High impact information on NUP120


Biological context of NUP120

  • Transfer of nup120 delta cells to 37 degrees C resulted in the nuclear accumulation of poly(A)+ mRNA, extensive fragmentation of the nucleolus, spindle defects, and cell death [2].

Other interactions of NUP120

  • Independent experiments are consistent with the FRET results: Nup120 localization is perturbed in the nic96-1 mutant, as is Nup82 localization in the nup116Delta mutant [4].

Analytical, diagnostic and therapeutic context of NUP120


  1. Structure and assembly of the Nup84p complex. Siniossoglou, S., Lutzmann, M., Santos-Rosa, H., Leonard, K., Mueller, S., Aebi, U., Hurt, E. J. Cell Biol. (2000) [Pubmed]
  2. Nup120p: a yeast nucleoporin required for NPC distribution and mRNA transport. Aitchison, J.D., Blobel, G., Rout, M.P. J. Cell Biol. (1995) [Pubmed]
  3. Nuclear pore complex clustering and nuclear accumulation of poly(A)+ RNA associated with mutation of the Saccharomyces cerevisiae RAT2/NUP120 gene. Heath, C.V., Copeland, C.S., Amberg, D.C., Del Priore, V., Snyder, M., Cole, C.N. J. Cell Biol. (1995) [Pubmed]
  4. In situ analysis of spatial relationships between proteins of the nuclear pore complex. Damelin, M., Silver, P.A. Biophys. J. (2002) [Pubmed]
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