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Gene Review:

NUP120 - Nup120p

Saccharomyces cerevisiae S288c

Synonyms: Nuclear pore protein NUP120, Nucleoporin NUP120, RAT2, YKL057C, YKL313, ...

Aitchison, J.D. et al., Heath, C.V. et al., Damelin, M. et al., Siniossoglou, S. et al.

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High impact information on NUP120

For the assembly of the complex, Nup85p, Nup120p, and Nup145p-C are essential [1].
Deletion of the NUP120 gene caused clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth [2].
Nup120p corresponds to the open reading frame (ORF) YKL057c identified by the yeast genome sequencing project [2].
The phenotypes seen in cells carrying a disruption of the RAT2 gene were very similar to those seen with the rat2-1 and rat2-2 alleles [3].
Nuclear pore complex clustering and nuclear accumulation of poly(A)+ RNA associated with mutation of the Saccharomyces cerevisiae RAT2/NUP120 gene [3].

Biological context of NUP120

Transfer of nup120 delta cells to 37 degrees C resulted in the nuclear accumulation of poly(A)+ mRNA, extensive fragmentation of the nucleolus, spindle defects, and cell death [2].

Other interactions of NUP120

Independent experiments are consistent with the FRET results: Nup120 localization is perturbed in the nic96-1 mutant, as is Nup82 localization in the nup116Delta mutant [4].

Analytical, diagnostic and therapeutic context of NUP120

Nup120p was localized to the NPC using a protein A-tagged chimera in situ by indirect immunofluorescence microscopy [2].
Peptide sequence analysis of a polypeptide with a M(r) of approximately 100,000 present in a highly enriched yeast NPC fraction identified a novel yeast nucleoporin we term Nup120p [2].

References

Structure and assembly of the Nup84p complex. Siniossoglou, S., Lutzmann, M., Santos-Rosa, H., Leonard, K., Mueller, S., Aebi, U., Hurt, E. J. Cell Biol. (2000) [Pubmed]
Nup120p: a yeast nucleoporin required for NPC distribution and mRNA transport. Aitchison, J.D., Blobel, G., Rout, M.P. J. Cell Biol. (1995) [Pubmed]
Nuclear pore complex clustering and nuclear accumulation of poly(A)+ RNA associated with mutation of the Saccharomyces cerevisiae RAT2/NUP120 gene. Heath, C.V., Copeland, C.S., Amberg, D.C., Del Priore, V., Snyder, M., Cole, C.N. J. Cell Biol. (1995) [Pubmed]
In situ analysis of spatial relationships between proteins of the nuclear pore complex. Damelin, M., Silver, P.A. Biophys. J. (2002) [Pubmed]

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AGOS_ABR073C	Ashbya gossypii ATCC 10895
KLLA0C12771g	Kluyveromyces lactis NRRL Y-1140

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