Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

MDM20 - Mdm20p

Saccharomyces cerevisiae S288c

Synonyms: DEC1, Dislikes extra CIN8 protein 1, Mitochondrial distribution and morphology protein 20, N-terminal acetyltransferase B complex subunit MDM20, NAA25, ...

Hermann, G.J. et al., Singer, J.M. et al., Caesar, R. et al., Yamada, K. et al.

Yamada, Kawata, Shou, Mizutani, Noguchi, Miyamoto,

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High impact information on MDM20

Synthetic lethality is also observed between mdm20 and tpm1 mutant strains [1].
The yeast gene, MDM20, is necessary for mitochondrial inheritance and organization of the actin cytoskeleton [1].
We present genetic evidence that Mdm20p functions cooperatively with Nat3p, the catalytic subunit of the NatB acetyltransferase [2].
The Saccharomyces cerevisiae N-terminal acetyltransferase NatB consists of the subunits Nat3p and Mdm20p [3].
Insulin induces the expression of the SHARP-2/Stra13/DEC1 gene via a phosphoinositide 3-kinase pathway [4].

References

The yeast gene, MDM20, is necessary for mitochondrial inheritance and organization of the actin cytoskeleton. Hermann, G.J., King, E.J., Shaw, J.M. J. Cell Biol. (1997) [Pubmed]
Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast. Singer, J.M., Shaw, J.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
The stress-induced Tfs1p requires NatB-mediated acetylation to inhibit carboxypeptidase Y and to regulate the protein kinase A pathway. Caesar, R., Blomberg, A. J. Biol. Chem. (2004) [Pubmed]
Insulin induces the expression of the SHARP-2/Stra13/DEC1 gene via a phosphoinositide 3-kinase pathway. Yamada, K., Kawata, H., Shou, Z., Mizutani, T., Noguchi, T., Miyamoto, K. J. Biol. Chem. (2003) [Pubmed]

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AGOS_AER019C	Ashbya gossypii ATCC 10895
KLLA0E17777g	Kluyveromyces lactis NRRL Y-1140

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