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Gene Review

TPM1  -  tropomyosin TPM1

Saccharomyces cerevisiae S288c

Synonyms: N2332, Tropomyosin-1, YNL079C
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Psychiatry related information on TPM1


High impact information on TPM1


Biological context of TPM1


Anatomical context of TPM1


Associations of TPM1 with chemical compounds

  • Despite this, three-dimensional reconstruction of electron microscope images of filaments in the presence of troponin and Ca(2+) showed tropomyosin to be in a position similar to that found for muscle actin filaments, where most of the myosin binding site is exposed [11].
  • To monitor binding of tropomyosin to yeast actin, we mutated S235 to C and labeled the actin with pyrene maleimide at both C235 and the normally reactive C374 [12].
  • The mutators exhibited a variety of responses to damaging agents such as UV light and ethidium bromide; especially in a representative mutant from the complementation group tpm1, the induction of rho- mutants was sensitive to UV light and resistant to ethidium bromide.(ABSTRACT TRUNCATED AT 250 WORDS)[13]

Physical interactions of TPM1

  • Despite its shorter length, Tpm2p can compete with Tpm1p for binding to F-actin [6].

Regulatory relationships of TPM1


Other interactions of TPM1

  • Synthetic lethality is also observed between mdm20 and tpm1 mutant strains [5].
  • Disruption of TPM1 is not lethal but results in the loss of actin cables and confers a partial defect in polarized secretion [15].
  • All other combinations of double mutations and the triple mutant lacking tropomyosin, Abp1p, and capping protein, are viable and their phenotypes are similar to or only slightly more severe than those of the single mutants [16].
  • Also, synthetic lethality between anc3 and sac6 mutations, and between anc4 and tpm1 mutations was observed [17].
  • The myo2-66 conditional mutation shows synthetic lethality with the TPM1 disruption, indicating that the MYO2 and TPM1 gene products may be involved in the same, or parallel function [7].

Analytical, diagnostic and therapeutic context of TPM1


  1. Mitochondrial inheritance: cell cycle and actin cable dependence of polarized mitochondrial movements in Saccharomyces cerevisiae. Simon, V.R., Karmon, S.L., Pon, L.A. Cell Motil. Cytoskeleton (1997) [Pubmed]
  2. Disruption of the single tropomyosin gene in yeast results in the disappearance of actin cables from the cytoskeleton. Liu, H.P., Bretscher, A. Cell (1989) [Pubmed]
  3. Developmental biology. New role for tropomyosin. St Johnston, D. Nature (1995) [Pubmed]
  4. A new tropomyosin essential for cytokinesis in the fission yeast S. pombe. Balasubramanian, M.K., Helfman, D.M., Hemmingsen, S.M. Nature (1992) [Pubmed]
  5. The yeast gene, MDM20, is necessary for mitochondrial inheritance and organization of the actin cytoskeleton. Hermann, G.J., King, E.J., Shaw, J.M. J. Cell Biol. (1997) [Pubmed]
  6. Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions. Drees, B., Brown, C., Barrell, B.G., Bretscher, A. J. Cell Biol. (1995) [Pubmed]
  7. Characterization of TPM1 disrupted yeast cells indicates an involvement of tropomyosin in directed vesicular transport. Liu, H., Bretscher, A. J. Cell Biol. (1992) [Pubmed]
  8. Mutations synthetically lethal with tpm1delta lie in genes involved in morphogenesis. Wang, T., Bretscher, A. Genetics (1997) [Pubmed]
  9. Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments. Lehman, W., Hatch, V., Korman, V., Rosol, M., Thomas, L., Maytum, R., Geeves, M.A., Van Eyk, J.E., Tobacman, L.S., Craig, R. J. Mol. Biol. (2000) [Pubmed]
  10. Polycystin-2 associates with tropomyosin-1, an actin microfilament component. Li, Q., Dai, Y., Guo, L., Liu, Y., Hao, C., Wu, G., Basora, N., Michalak, M., Chen, X.Z. J. Mol. Biol. (2003) [Pubmed]
  11. An actin subdomain 2 mutation that impairs thin filament regulation by troponin and tropomyosin. Korman, V.L., Hatch, V., Dixon, K.Y., Craig, R., Lehman, W., Tobacman, L.S. J. Biol. Chem. (2000) [Pubmed]
  12. Differential interaction of cardiac, skeletal muscle, and yeast tropomyosins with fluorescent (pyrene235) yeast actin. Chen, W., Wen, K.K., Sens, A.E., Rubenstein, P.A. Biophys. J. (2006) [Pubmed]
  13. Repair properties in yeast mitochondrial DNA mutators. Backer, J., Foury, F. Curr. Genet. (1985) [Pubmed]
  14. Modulation of myosin function by isoform-specific properties of Saccharomyces cerevisiae and muscle tropomyosins. Strand, J., Nili, M., Homsher, E., Tobacman, L.S. J. Biol. Chem. (2001) [Pubmed]
  15. The rho-GAP encoded by BEM2 regulates cytoskeletal structure in budding yeast. Wang, T., Bretscher, A. Mol. Biol. Cell (1995) [Pubmed]
  16. Unexpected combinations of null mutations in genes encoding the actin cytoskeleton are lethal in yeast. Adams, A.E., Cooper, J.A., Drubin, D.G. Mol. Biol. Cell (1993) [Pubmed]
  17. Genetic evidence for functional interactions between actin noncomplementing (Anc) gene products and actin cytoskeletal proteins in Saccharomyces cerevisiae. Vinh, D.B., Welch, M.D., Corsi, A.K., Wertman, K.F., Drubin, D.G. Genetics (1993) [Pubmed]
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