The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

NAT3  -  Nat3p

Saccharomyces cerevisiae S288c

Synonyms: N-terminal acetyltransferase B complex catalytic subunit NAT3, NAA20, NatB Nalpha terminal acetyltransferase 3, NatB complex subunit NAT3, RAD56, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on NAT3

  • We investigated the three N-terminal acetyltransferases (NATs), Ard1p/Nat1p, Nat3p and Mak3p [1].
  • We present genetic evidence that Mdm20p functions cooperatively with Nat3p, the catalytic subunit of the NatB acetyltransferase [2].
  • The involvement of Nat3p and Tfs1p in PKA signaling was supported by caffeine growth inhibition studies [3].
  • The 20 S proteasome subunits were purified from the normal strain and each of the deletion mutants, nat1, mak3, and nat3 [4].
  • N(alpha)-terminal acetylation occurs in the yeast Saccharomyces cerevisiae by any of three N-terminal acetyltransferases (NAT), NatA, NatB, and NatC, which contain Ard1p, Nat3p and Mak3p catalytic subunits, respectively [5].

Biological context of NAT3


Other interactions of NAT3

  • We found that strains deleted for either NAT3 or MDM20 displayed different growth rates and morphologies in specific stress conditions, demonstrating that the two NatB subunits have partly individual functions [7].


  1. Identification and specificities of N-terminal acetyltransferases from Saccharomyces cerevisiae. Polevoda, B., Norbeck, J., Takakura, H., Blomberg, A., Sherman, F. EMBO J. (1999) [Pubmed]
  2. Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast. Singer, J.M., Shaw, J.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. The stress-induced Tfs1p requires NatB-mediated acetylation to inhibit carboxypeptidase Y and to regulate the protein kinase A pathway. Caesar, R., Blomberg, A. J. Biol. Chem. (2004) [Pubmed]
  4. N(alpha)-acetylation and proteolytic activity of the yeast 20 S proteasome. Kimura, Y., Takaoka, M., Tanaka, S., Sassa, H., Tanaka, K., Polevoda, B., Sherman, F., Hirano, H. J. Biol. Chem. (2000) [Pubmed]
  5. N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins. Polevoda, B., Sherman, F. J. Mol. Biol. (2003) [Pubmed]
  6. The action of N-terminal acetyltransferases on yeast ribosomal proteins. Arnold, R.J., Polevoda, B., Reilly, J.P., Sherman, F. J. Biol. Chem. (1999) [Pubmed]
  7. Physiological importance and identification of novel targets for the N-terminal acetyltransferase NatB. Caesar, R., Warringer, J., Blomberg, A. Eukaryotic Cell (2006) [Pubmed]
WikiGenes - Universities