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Gene Review

SLC45A3  -  solute carrier family 45, member 3

Homo sapiens

Synonyms: IPCA-2, IPCA-6, IPCA-8, IPCA6, PCANAP2, ...
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Disease relevance of SLC45A3

  • These results validate prostein as a prostate-specific marker with potential utility in the diagnosis and treatment of prostate cancer [1].

High impact information on SLC45A3

  • The prostein gene is located on chromosome 1 at the WI-9641 locus between q32 and q42 [1].
  • Prostein expression is androgen responsive because treatment of LNCaP cells with androgen up-regulates prostein message and protein expression levels [1].
  • Immunohistochemical staining using a mouse monoclonal antibody generated against prostein demonstrates that this protein is specifically detected in prostate tissues both at the plasma membrane and in the cytoplasm [1].
  • Furthermore, prostein mRNA expression does not appear to be prostate tumor grade related and is restricted exclusively to prostate cell lines [1].
  • Identification of naturally processed CD8 T cell epitopes from prostein, a prostate tissue-specific vaccine candidate [2].

Biological context of SLC45A3


Anatomical context of SLC45A3


Analytical, diagnostic and therapeutic context of SLC45A3

  • Prostein mRNA is shown to be uniquely expressed in normal and cancerous prostate tissues using Northern blot, eDNA microarray, and real-time PCR analyses [1].
  • Our data suggest that prostein is a suitable candidate to be included in a T-cell-based immunotherapy of prostate cancer [3].
  • Furthermore, the naturally processed peptide epitopes identified provide tools for the development of peptide-based vaccination strategies against prostate cancer and for monitoring of prostein-specific responses in vaccinated patients [2].


  1. Identification and characterization of prostein, a novel prostate-specific protein. Xu, J., Kalos, M., Stolk, J.A., Zasloff, E.J., Zhang, X., Houghton, R.L., Filho, A.M., Nolasco, M., Badaró, R., Reed, S.G. Cancer Res. (2001) [Pubmed]
  2. Identification of naturally processed CD8 T cell epitopes from prostein, a prostate tissue-specific vaccine candidate. Friedman, R.S., Spies, A.G., Kalos, M. Eur. J. Immunol. (2004) [Pubmed]
  3. Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein. Kiessling, A., Stevanovic, S., Füssel, S., Weigle, B., Rieger, M.A., Temme, A., Rieber, E.P., Schmitz, M. Br. J. Cancer (2004) [Pubmed]
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