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Gene Review

HIR2  -  Hir2p

Saccharomyces cerevisiae S288c

Synonyms: Histone transcription regulator 2, OR26.31, Protein HIR2, YOR038C
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Disease relevance of HIR2


High impact information on HIR2

  • Here we show that ectopic expression of HIRA, the likely human ortholog of two cell cycle-regulated repressors of histone gene transcription in yeast (Hir1p and Hir2p), represses transcription of histones and that this, in turn, triggers a concerted block of DNA synthesis [2].
  • Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle [3].
  • Also, Asf1p bound to the Hir1p and Hir2p proteins in vitro and in cell extracts [4].
  • CKB2 is located on the right arm of chromosome XV between the HIR2 and WHI2 loci and has not been previously identified genetically [5].
  • Slm9 is most similar to Hir2, the histone gene regulator in budding yeast [6].

Biological context of HIR2


Other interactions of HIR2

  • When Hir1p and Hir2p were artificially tethered to yeast promoters, each protein repressed transcription, suggesting that they represent a new class of transcriptional corepressors [3].
  • Furthermore, increased expression of genes encoding Asf1p, Hir1p, and Hir2p suppressed the apc5(CA) Ts- defect in a CAF-I-dependent manner [9].


  1. A human homolog of the S. cerevisiae HIR1 and HIR2 transcriptional repressors cloned from the DiGeorge syndrome critical region. Lamour, V., Lécluse, Y., Desmaze, C., Spector, M., Bodescot, M., Aurias, A., Osley, M.A., Lipinski, M. Hum. Mol. Genet. (1995) [Pubmed]
  2. Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/cdk2 activity. Nelson, D.M., Ye, X., Hall, C., Santos, H., Ma, T., Kao, G.D., Yen, T.J., Harper, J.W., Adams, P.D. Mol. Cell. Biol. (2002) [Pubmed]
  3. Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle. Spector, M.S., Raff, A., DeSilva, H., Lee, K., Osley, M.A. Mol. Cell. Biol. (1997) [Pubmed]
  4. Yeast histone deposition protein Asf1p requires Hir proteins and PCNA for heterochromatic silencing. Sharp, J.A., Fouts, E.T., Krawitz, D.C., Kaufman, P.D. Curr. Biol. (2001) [Pubmed]
  5. Cloning and disruption of CKB2, the gene encoding the 32-kDa regulatory beta'-subunit of Saccharomyces cerevisiae casein kinase II. Reed, J.C., Bidwai, A.P., Glover, C.V. J. Biol. Chem. (1994) [Pubmed]
  6. Slm9, a novel nuclear protein involved in mitotic control in fission yeast. Kanoh, J., Russell, P. Genetics (2000) [Pubmed]
  7. HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression. Hall, C., Nelson, D.M., Ye, X., Baker, K., DeCaprio, J.A., Seeholzer, S., Lipinski, M., Adams, P.D. Mol. Cell. Biol. (2001) [Pubmed]
  8. Structural Organization of the WD repeat protein-encoding gene HIRA in the DiGeorge syndrome critical region of human chromosome 22. Lorain, S., Demczuk, S., Lamour, V., Toth, S., Aurias, A., Roe, B.A., Lipinski, M. Genome Res. (1996) [Pubmed]
  9. Contribution of CAF-I to anaphase-promoting-complex-mediated mitotic chromatin assembly in Saccharomyces cerevisiae. Harkness, T.A., Arnason, T.G., Legrand, C., Pisclevich, M.G., Davies, G.F., Turner, E.L. Eukaryotic Cell (2005) [Pubmed]
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