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Gene Review: 

NOB1  -  Nob1p

Saccharomyces cerevisiae S288c

Synonyms: 20S-pre-rRNA D-site endonuclease NOB1, NIN1-binding protein, Pre-rRNA-processing endonuclease NOB1, YOR056C, YOR29-07
 
 
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High impact information on NOB1

  • Overexpression of NOB1 overrode the defects in maturation of the 20S proteasome of ump1Delta cells, and temperature-sensitive nob1 and pno1 mutants exhibited defects in the processing of the beta subunits and in the assembly of the 20S and the 26S proteasomes [1].
  • NOB1 was found to be an essential gene, encoding a protein of 459 amino acid residues [2].

References

  1. Nob1p is required for biogenesis of the 26S proteasome and degraded upon its maturation in Saccharomyces cerevisiae. Tone, Y., Toh-E, A. Genes Dev. (2002) [Pubmed]
  2. Nob1p, a new essential protein, associates with the 26S proteasome of growing saccharomyces cerevisiae cells. Tone, Y., Tanahashi, N., Tanaka, K., Fujimuro, M., Yokosawa, H., Toh-e, A. Gene (2000) [Pubmed]
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