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Gene Review

YNG1  -  Yng1p

Saccharomyces cerevisiae S288c

Synonyms: ING1 homolog 1, Protein YNG1, YOR064C, YOR29-15
 
 
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Disease relevance of YNG1

  • Using the toxicity of YNG1 overexpression as a tool, we showed that Yng1p interacts with the amino-terminal tail of histone H3 and that this interaction can be disrupted by loss of lysine 4 methylation within this tail [1].
 

High impact information on YNG1

  • There are three members of the ING family in Saccharomyces cerevisiae: Yng1p, Yng2p, and Pho23p [1].
  • The yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone h3 [1].
  • Additionally, we mapped the region of Yng1p required for overexpression of toxicity to the PHD finger, showed that this region capable of binding lysine 4-methylated histone H3 in vitro, and demonstrated that mutations of the PHD finger that abolish binding in vitro are no longer toxic in vivo [1].
  • These results identify a novel function for the Yng1p PHD finger in promoting stabilization of the NuA3 complex at chromatin through recognition of histone H3 lysine 4 methylation [1].
  • Instead, we find that Yng1p mediates the interaction of Sas3p with nucleosomes and is thus required for the ability of NuA3 to modify histone tails [2].
 

Biological context of YNG1

 

Other interactions of YNG1

  • We further demonstrated by coimmunoprecipitation that HA-Yng1, HA-Yng2, HA-Pho23, and HA-Ing1 are associated with HAT activities in yeast [4].

References

  1. The yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone h3. Martin, D.G., Baetz, K., Shi, X., Walter, K.L., Macdonald, V.E., Wlodarski, M.J., Gozani, O., Hieter, P., Howe, L. Mol. Cell. Biol. (2006) [Pubmed]
  2. Yng1p modulates the activity of Sas3p as a component of the yeast NuA3 Hhistone acetyltransferase complex. Howe, L., Kusch, T., Muster, N., Chaterji, R., Yates, J.R., Workman, J.L. Mol. Cell. Biol. (2002) [Pubmed]
  3. Opposite role of yeast ING family members in p53-dependent transcriptional activation. Nourani, A., Howe, L., Pray-Grant, M.G., Workman, J.L., Grant, P.A., Côté, J. J. Biol. Chem. (2003) [Pubmed]
  4. Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities. Loewith, R., Meijer, M., Lees-Miller, S.P., Riabowol, K., Young, D. Mol. Cell. Biol. (2000) [Pubmed]
 
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