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Gene Review

SAS3  -  Sas3p

Saccharomyces cerevisiae S288c

Synonyms: Histone acetyltransferase SAS3, Something about silencing protein 3, YBL0507, YBL0515, YBL052C
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High impact information on SAS3

  • We have identified the Saccharomyces cerevisiae genes SAS2 and SAS3 through a screen for enhancers of sir1 epigenetic silencing defects [1].
  • Simultaneous disruption of SAS3, the homolog of the MOZ leukemia gene, and GCN5, the hGCN5/PCAF homolog, is synthetically lethal due to loss of acetyltransferase activity [2].
  • The something about silencing (Sas) 2 protein of Saccharomyces cerevisiae, a member of the MYST (MOZ, Ybf2/Sas3, Sas2, and TIP60) acetyltransferase family, promotes silencing at HML and telomeres [3].
  • Sas3 mediates interaction of the NuA3 complex with Spt16 both in vivo and in vitro [4].
  • With a chromatin pulldown assay, we found that NuA3 interacts with the histone H3 amino-terminal tail, and loss of the H3 tail recapitulates phenotypes associated with loss of SAS3 [5].

Biological context of SAS3


Other interactions of SAS3

  • SAS3 was originally isolated as a gene related to SAS2, which encodes a positive regulator of transcriptional silencing in yeast [7].


  1. Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases. Reifsnyder, C., Lowell, J., Clarke, A., Pillus, L. Nat. Genet. (1996) [Pubmed]
  2. Histone H3 specific acetyltransferases are essential for cell cycle progression. Howe, L., Auston, D., Grant, P., John, S., Cook, R.G., Workman, J.L., Pillus, L. Genes Dev. (2001) [Pubmed]
  3. The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1. Osada, S., Sutton, A., Muster, N., Brown, C.E., Yates, J.R., Sternglanz, R., Workman, J.L. Genes Dev. (2001) [Pubmed]
  4. The something about silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)-FACT complex. John, S., Howe, L., Tafrov, S.T., Grant, P.A., Sternglanz, R., Workman, J.L. Genes Dev. (2000) [Pubmed]
  5. Methylation of histone H3 mediates the association of the NuA3 histone acetyltransferase with chromatin. Martin, D.G., Grimes, D.E., Baetz, K., Howe, L. Mol. Cell. Biol. (2006) [Pubmed]
  6. Opposite role of yeast ING family members in p53-dependent transcriptional activation. Nourani, A., Howe, L., Pray-Grant, M.G., Workman, J.L., Grant, P.A., Côté, J. J. Biol. Chem. (2003) [Pubmed]
  7. Sas3 is a histone acetyltransferase and requires a zinc finger motif. Takechi, S., Nakayama, T. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  8. Yng1p modulates the activity of Sas3p as a component of the yeast NuA3 Hhistone acetyltransferase complex. Howe, L., Kusch, T., Muster, N., Chaterji, R., Yates, J.R., Workman, J.L. Mol. Cell. Biol. (2002) [Pubmed]
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