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Gene Review

ATX2  -  Mn(2+) transporter ATX2

Saccharomyces cerevisiae S288c

Synonyms: Metal homeostasis factor ATX2, YOR079C, YOR29-30
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Disease relevance of ATX2


High impact information on ATX2

  • The effect of ATX2 overexpression on manganese accumulation and oxygen resistance is similar to what we have previously reported for mutations in PMR1, which encodes a manganese-trafficking protein that also resides in a vesicular compartment [1].
  • Suppression of oxidative damage by Saccharomyces cerevisiae ATX2, which encodes a manganese-trafficking protein that localizes to Golgi-like vesicles [1].
  • Multiple copies of ATX2 were found to reverse the aerobic auxotrophies of sod1(delta) mutants for lysine and methionine and also to enhance the resistance of these yeast strains to paraquat and atmospheric levels of oxygen [1].
  • Third, ATX2 was incapable of suppressing oxidative damage in cells depleted of manganese ions or lacking the plasma membrane transporter for manganese [1].
  • With indirect immunofluorescence microscopy, Atx2p exhibited a punctate pattern of staining typical of the Golgi apparatus, and upon subcellular fractionation, Atx2p colocalized with a biochemical marker for the yeast Golgi apparatus [1].

Biological context of ATX2


Anatomical context of ATX2

  • Our studies indicate that Atx2p localizes to the membrane of a vesicular compartment in yeast cells reminiscent of the Golgi apparatus [1].

Associations of ATX2 with chemical compounds

  • First, overexpression of ATX2 caused cells to accumulate increased levels of manganese [1].


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