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Gene Review

SCEI  -  intron-encoded endonuclease I-SceI

Saccharomyces cerevisiae S288c

Synonyms: 21S rRNA intron maturase, Homing endonuclease omega, Intron-encoded endonuclease I-SceI, OMEGA, Q0160, ...
 
 
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Disease relevance of SCEI

  • A supportive correlation is that Omega and Cjw1, which are distinguished from other mycobacteriophages by their possession of a Pnkp enzyme, are also unique among the mycobacteriophages in their specification of putative RNA ligases [1].
 

High impact information on SCEI

  • A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation [2].
  • Sequence analysis of a 102-kD protein, identified previously as a specific Omega RNA-binding protein, revealed homology to the HSP101/HSP104/ClpB family of heat shock proteins and its expression in yeast complemented a thermotolerance defect caused by a deletion of the HSP104 gene [3].
  • The 5' leader (Omega) of tobacco mosaic viral RNA functions as a translational enhancer [3].
  • The mitochondrial intron-encoded endonuclease I-SceI of Saccharomyces cerevisiae has an 18-bp recognition sequence and, therefore, has a very low probability of cutting DNA, even within large genomes [4].
  • Residues 75-78 form a tight turn within Omega-loop D in Saccharomyces cerevisiae iso-1-cytochrome c. Directed, random mutagenesis of invariant residues proline 76 and glycine 77 in this turn were analyzed for the in vivo functionality and level of protein within the cell [5].
 

Associations of SCEI with chemical compounds

 

Analytical, diagnostic and therapeutic context of SCEI

  • The optimized electroporation condition was 900 V, 25 microF, and 200 Omega. The DNA concentration did not influence the transformation [7].

References

 
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