Disease relevance of Mycobacteriophages

• Chemistry of the lyxose-containing mycobacteriophage receptors of Mycobacterium phlei/Mycobacterium smegmatis [1].
• Four putative promoters of the temperate mycobacteriophage L1 were cloned by detecting the beta-galactosidase reporter expression in E. coli transformants that carried L1 specific operon-fusion library [2].
• Efficient and stable chromosomal integration of recombinant plasmids into BCG was achieved using a DNA segment containing the mycobacteriophage L5 attachment site and integrase coding sequence [3].

High impact information on Mycobacteriophages

• A supportive correlation is that Omega and Cjw1, which are distinguished from other mycobacteriophages by their possession of a Pnkp enzyme, are also unique among the mycobacteriophages in their specification of putative RNA ligases [4].
• Molecular cloning and sequencing of the attachment site and integrase gene of the temperate mycobacteriophage FRAT1 [5].
• We describe here the development of a bacteriophage replication assay for the detection of Mycobacterium tuberculosis by using mycobacteriophage D29 [6].
• Mycobacteriophage D29 integrase-mediated recombination: specificity of mycobacteriophage integration [7].
• Specific identification of Mycobacterium tuberculosis with the luciferase reporter mycobacteriophage: use of p-nitro-alpha-acetylamino-beta-hydroxy propiophenone [8].

Chemical compound and disease context of Mycobacteriophages

• Inhibition of DNA injection from mycobacteriophage I3 by Tween-80 [9].
• Haptenic oligosaccharides in antigenic variants of mycobacterial C-mycosides antagonize lipid receptor activity for mycobacteriophage D4 by masking a methylated rhamnose [10].
• The association of nucleoside triphosphate molecules and calcium ions with purified particles of mycobacteriophage 13 has been documented [11].
• Four ORFs were identified: one with strong homology to dCMP deaminase genes; one homologous to mycobacteriophage L5 gene 36, whose function is unknown; one encoding a possible excisase; and one encoding an integrase [12].
• Inactivation of mycobacteriophage D29 using ferrous ammonium sulphate as a tool for the detection of viable Mycobacterium smegmatis and M. tuberculosis [13].

Gene context of Mycobacteriophages

• We also present the sequences of the putative attP site and integrase protein of the cryptic prophage-like element phiRv2, and compare them to those of mycobacteriophages L5 and D29 [7].
• Cloning and sequencing analysis of the repressor gene of temperate mycobacteriophage L1 [14].

References