Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

MIH1 - Mih1p

Saccharomyces cerevisiae S288c

Synonyms: M-phase inducer phosphatase, Mitosis initiation protein MIH1, Mitotic inducer homolog, YM9532.01C, YM9973.10C, ...

Sohn, J. et al., Sgarlata, C. et al., Sia, R.A. et al., Seth, D. et al., Russell, P. et al.

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High impact information on MIH1

Expression of wee1+ in a mih1- strain prevents the initiation of mitosis [1].
The conditional knockout of the cdc25 homolog (mih1) in Saccharomyces cerevisiae can be complemented by the wild type but not by the hot spot variants, indicating that protein substrate recognition by the Cdc25 phosphatases is an essential and evolutionarily conserved feature [2].
The timing of nuclear division in cells that cannot make a bud is exquisitely sensitive to the dosage of SWE1 and MIH1 genes, which control phosphorylation of Cdc28 at tyrosine 19 [3].

Biological context of MIH1

Redox control of cell cycle progression via Cdc25 phosphatase (Mih1p) in S. cerevisiae [4].

Other interactions of MIH1

In the fission yeast, Schizosaccharomyces pombe, Cdc25 is required for entry into mitosis, while in the budding yeast Saccharomyces cerevisiae, Mih1 (the homologue of Cdc25) is not required for entry into mitosis or for viability [5].

References

Conservation of mitotic controls in fission and budding yeasts. Russell, P., Moreno, S., Reed, S.I. Cell (1989) [Pubmed]
Remote hot spots mediate protein substrate recognition for the Cdc25 phosphatase. Sohn, J., Kristjánsdóttir, K., Safi, A., Parker, B., Kiburz, B., Rudolph, J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast. Sia, R.A., Herald, H.A., Lew, D.J. Mol. Biol. Cell (1996) [Pubmed]
Redox control of cell cycle progression via Cdc25 phosphatase (Mih1p) in S. cerevisiae. Seth, D., Rudolph, J. Cell Cycle (2006) [Pubmed]
The cdc25 phosphatase is essential for the G2/M phase transition in the basidiomycete yeast Ustilago maydis. Sgarlata, C., Pérez-Martín, J. Mol. Microbiol. (2005) [Pubmed]

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