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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MBD3L1  -  methyl-CpG binding domain protein 3-like 1

Homo sapiens

Synonyms: MBD3-like protein 1, MBD3L, Methyl-CpG-binding domain protein 3-like 1
 
 
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High impact information on MBD3L1

  • The methylated-CpG island recovery assay (MIRA), which is based on the high affinity of the MBD2/MBD3L1 complex for methylated DNA, has been used to detect cell type-dependent differences in DNA methylation on a microarray platform [1].
  • Unlike MBD3L1, which is specifically expressed in haploid male germ cells, MBD3L2 expression is more widespread [2].
  • MBD3L1 knockout mice were created and were found to be viable and fertile, indicating that MBD3L1 may not be essential or there is functional redundancy (through MBD3) in this pathway [3].
  • During spermatogenesis, expression of MBD3L1 is observed only in round spermatids, suggesting a role for the gene product in the postmeiotic stages of male germ cell development [4].
  • The MBD3L1 gene is expressed specifically in testis [4].
 

Associations of MBD3L1 with chemical compounds

  • In vivo, MBD3L1 associates with and colocalizes with MBD2 but not with MBD3 and is recruited to 5-methylcytosine-rich pericentromeric heterochromatin in mouse cells [3].
 

Physical interactions of MBD3L1

 

Regulatory relationships of MBD3L1

  • MBD3L1 enhances transcriptional repression of methylated DNA by MBD2 [3].
 

Other interactions of MBD3L1

References

  1. MIRA-Assisted Microarray Analysis, a New Technology for the Determination of DNA Methylation Patterns, Identifies Frequent Methylation of Homeodomain-Containing Genes in Lung Cancer Cells. Rauch, T., Li, H., Wu, X., Pfeifer, G.P. Cancer Res. (2006) [Pubmed]
  2. MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing. Jin, S.G., Jiang, C.L., Rauch, T., Li, H., Pfeifer, G.P. J. Biol. Chem. (2005) [Pubmed]
  3. MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex. Jiang, C.L., Jin, S.G., Pfeifer, G.P. J. Biol. Chem. (2004) [Pubmed]
  4. MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor. Jiang, C.L., Jin, S.G., Lee, D.H., Lan, Z.J., Xu, X., O'Connor, T.R., Szabó, P.E., Mann, J.R., Cooney, A.J., Pfeifer, G.P. Genomics (2002) [Pubmed]
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