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CTF18  -  Ctf18p

Saccharomyces cerevisiae S288c

Synonyms: CHL12, Chromosome transmission fidelity protein 18, YM9582.03C, YMR078C
 
 
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High impact information on CTF18

  • Surprisingly CTF18 is not required for Ku or Sir4-mediated peripheral tethering of a nontelomeric chromosome locus [1].
  • We report that Ctf18, Ctf8, and Dcc1, the subunits of a Replication Factor C (RFC)-like complex, are essential for the perinuclear positioning of telomeres [1].
  • We find that the mislocalized telomeres of ctf18 cells still replicate late, showing that late DNA replication does not require peripheral positioning during G1 [1].
  • The physical and genetic interactions between CTF4, CTF18, and core components of replication fork complexes observed in this study and others suggest that both gene products act in association with the replication fork to facilitate sister chromatid cohesion [2].
  • CTF4 and CTF18 are required for high-fidelity chromosome segregation [2].
 

Biological context of CTF18

  • The Ctf18 RFC-like complex positions yeast telomeres but does not specify their replication time [1].
  • Analysis of the sequence upstream of the CHL12 open reading frame revealed the presence of two imperfect copies of MluI motif, ACGCGT, a sequence associated with many DNA metabolism genes in yeast [3].
  • Most of cells carrying the null chl12 mutation arrested as large budded cells with the nucleus in the neck at nonpermissive temperature that typical for cell division cycle (cdc) mutants that arrest in the cell cycle at a point either immediately preceding M phase or during S phase [3].
  • A strain containing a null allele of CHL12 was viable under standard growth conditions, and as well as original mutants exhibited an increase in the level of spontaneous mitotic recombination, slow growth and cold-sensitive phenotypes [3].
  • We have analyzed the CHL12 gene, earlier identified in a screen for yeast mutants with increased rates of mitotic loss of chromosome III and circular centromeric plasmids [3].
 

Other interactions of CTF18

  • Based on tetrad analysis, chl12, chl14 and chl15 correspond to mutations in single nuclear genes [4].
  • Cell cycle arrest of the chl12 mutant requires the RAD9 gene [3].
  • A genomic clone of CHL12 was isolated and used to map its physical position on the right arm of chromosome XIII near the ADH3 locus [3].
  • Genetic and biochemical data indicate that the Elg1, Ctf18 and Rad24 RLCs work in three separate pathways important for maintaining the integrity of the genome and for coping with various genomic stresses [5].

References

  1. The Ctf18 RFC-like complex positions yeast telomeres but does not specify their replication time. Hiraga, S., Robertson, E.D., Donaldson, A.D. EMBO J. (2006) [Pubmed]
  2. Saccharomyces cerevisiae CTF18 and CTF4 are required for sister chromatid cohesion. Hanna, J.S., Kroll, E.S., Lundblad, V., Spencer, F.A. Mol. Cell. Biol. (2001) [Pubmed]
  3. CHL12, a gene essential for the fidelity of chromosome transmission in the yeast Saccharomyces cerevisiae. Kouprina, N., Kroll, E., Kirillov, A., Bannikov, V., Zakharyev, V., Larionov, V. Genetics (1994) [Pubmed]
  4. Identification and genetic mapping of CHL genes controlling mitotic chromosome transmission in yeast. Kouprina, N., Tsouladze, A., Koryabin, M., Hieter, P., Spencer, F., Larionov, V. Yeast (1993) [Pubmed]
  5. The Elg1 replication factor C-like complex: a novel guardian of genome stability. Aroya, S.B., Kupiec, M. DNA Repair (Amst.) (2005) [Pubmed]
 
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