Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

ROT1 - Rot1p

Saccharomyces cerevisiae S288c

Synonyms: Protein ROT1, Reversal of TOR2 lethality protein 1, YM8325.01, YMR200W

Takeuchi, M. et al., Machi, K. et al., Juanes, M.A. et al., Takeuchi, M. et al., Bickle, M. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ROT1

ROT2 encodes glucosidase II, and ROT1 and BIG1 encode novel proteins [1].
Deletion of ROT1 caused cell aggregation and an abnormal morphology [2].
Although ROT1 is essential for growth of Saccharomyces cerevisiae strain BY4741, the growth of a rot1Delta haploid was partially restored by the addition of 0.6 M sorbitol to the growth medium [2].
ROT1 genetically interacted with several ER chaperone genes including KAR2, and the rot1-2 mutation triggered the unfolded protein response [3].
Mutation of the ROT1 gene caused defects in cell wall synthesis and lysis of autophagic bodies [4].

Biological context of ROT1

Rot1 is an essential ER membrane protein and may be involved in protein folding [4].

Anatomical context of ROT1

We recently reported that a yeast protein, Rot1, is a putative cofactor of BiP, an endoplasmic reticulum (ER)-localized Hsp70 [4].

Regulatory relationships of ROT1

In fact, overexpression of CLB2 is toxic when ROT1 is partially inactivated, and reciprocally, deletion of CLB2 suppresses the lethality of the rot1 mutant, which indicates a functional antagonism between Clb2 and Rot1 [5].

References

Cell wall integrity modulates RHO1 activity via the exchange factor ROM2. Bickle, M., Delley, P.A., Schmidt, A., Hall, M.N. EMBO J. (1998) [Pubmed]
Rot1p of Saccharomyces cerevisiae is a putative membrane protein required for normal levels of the cell wall 1,6-beta-glucan. Machi, K., Azuma, M., Igarashi, K., Matsumoto, T., Fukuda, H., Kondo, A., Ooshima, H. Microbiology (Reading, Engl.) (2004) [Pubmed]
Saccharomyces cerevisiae Rot1p Is an ER-Localized Membrane Protein That May Function with BiP/Kar2p in Protein Folding. Takeuchi, M., Kimata, Y., Hirata, A., Oka, M., Kohno, K. J. Biochem. (2006) [Pubmed]
Causal links between protein folding in the ER and events along the secretory pathway. Takeuchi, M., Kimata, Y., Kohno, K. Autophagy. (2006) [Pubmed]
Rot1 plays an antagonistic role to Clb2 in actin cytoskeleton dynamics throughout the cell cycle. Juanes, M.A., Queralt, E., Bañó, M.C., Igual, J.C. J. Cell. Sci. (2007) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AGOS_AFL175C	Ashbya gossypii ATCC 10895
KLLA0F06468g	Kluyveromyces lactis NRRL Y-1140
SPAC31G5.02	Schizosaccharomyces pombe 972h-

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.