Gene Review:
HSPA5 - heat shock 70kDa protein 5 (glucose...
Homo sapiens
Synonyms:
78 kDa glucose-regulated protein, BIP, BiP, Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78, GRP-78, ...
- Enhanced selenium effect on growth arrest by BiP/GRP78 knockdown in p53-null human prostate cancer cells. Zu, K., Bihani, T., Lin, A., Park, Y.M., Mori, K., Ip, C. Oncogene (2006)
- Activation of the grp78 and grp94 promoters by hepatitis C virus E2 envelope protein. Liberman, E., Fong, Y.L., Selby, M.J., Choo, Q.L., Cousens, L., Houghton, M., Yen, T.S. J. Virol. (1999)
- Expression of stress response protein glucose regulated protein-78 mediated by c-Myb. Ramsay, R.G., Ciznadija, D., Mantamadiotis, T., Anderson, R., Pearson, R. Int. J. Biochem. Cell Biol. (2005)
- De-regulation of GRP stress protein expression in human breast cancer cell lines. Gazit, G., Lu, J., Lee, A.S. Breast Cancer Res. Treat. (1999)
- Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-epsilon/ERK/AP-1 signaling cascade. Song, M.S., Park, Y.K., Lee, J.H., Park, K. Cancer Res. (2001)
- Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer. Pootrakul, L., Datar, R.H., Shi, S.R., Cai, J., Hawes, D., Groshen, S.G., Lee, A.S., Cote, R.J. Clin. Cancer Res. (2006)
- GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis. Fu, Y., Li, J., Lee, A.S. Cancer Res. (2007)
- Different induction of GRP78 and CHOP as a predictor of sensitivity to proteasome inhibitors in thyroid cancer cells. Wang, H.Q., Du, Z.X., Zhang, H.Y., Gao, D.X. Endocrinology (2007)
- GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis. Lee, H.K., Xiang, C., Cazacu, S., Finniss, S., Kazimirsky, G., Lemke, N., Lehman, N.L., Rempel, S.A., Mikkelsen, T., Brodie, C. Neuro-oncology (2008)
- Functional polymorphisms of HSPA5: possible association with bipolar disorder. Kakiuchi, C., Ishiwata, M., Nanko, S., Kunugi, H., Minabe, Y., Nakamura, K., Mori, N., Fujii, K., Umekage, T., Tochigi, M., Kohda, K., Sasaki, T., Yamada, K., Yoshikawa, T., Kato, T. Biochem. Biophys. Res. Commun. (2005)
- Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. Katayama, T., Imaizumi, K., Sato, N., Miyoshi, K., Kudo, T., Hitomi, J., Morihara, T., Yoneda, T., Gomi, F., Mori, Y., Nakano, Y., Takeda, J., Tsuda, T., Itoyama, Y., Murayama, O., Takashima, A., St George-Hyslop, P., Takeda, M., Tohyama, M. Nat. Cell Biol. (1999)
- Increased temporal cortex ER stress proteins in depressed subjects who died by suicide. Bown, C., Wang, J.F., MacQueen, G., Young, L.T. Neuropsychopharmacology (2000)
- Gene expression in the rat cerebral cortex: comparison of recovery sleep and hypnotic-induced sleep. Wisor, J.P., Morairty, S.R., Huynh, N.T., Steininger, T.L., Kilduff, T.S. Neuroscience (2006)
- Antigen processing and presentation by the class I major histocompatibility complex. York, I.A., Rock, K.L. Annu. Rev. Immunol. (1996)
- The gene disrupted in Marinesco-Sjögren syndrome encodes SIL1, an HSPA5 cochaperone. Anttonen, A.K., Mahjneh, I., Hämäläinen, R.H., Lagier-Tourenne, C., Kopra, O., Waris, L., Anttonen, M., Joensuu, T., Kalimo, H., Paetau, A., Tranebjaerg, L., Chaigne, D., Koenig, M., Eeg-Olofsson, O., Udd, B., Somer, M., Somer, H., Lehesjoki, A.E. Nat. Genet. (2005)
- ATP is required for in vitro assembly of MHC class I antigens but not for transfer of peptides across the ER membrane. Lévy, F., Gabathuler, R., Larsson, R., Kvist, S. Cell (1991)
- An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein. Munro, S., Pelham, H.R. Cell (1986)
- The translocon: a dynamic gateway at the ER membrane. Johnson, A.E., van Waes, M.A. Annu. Rev. Cell Dev. Biol. (1999)
- Stress protein GRP78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells. Miyake, H., Hara, I., Arakawa, S., Kamidono, S. J. Cell. Biochem. (2000)
- A stress-inducible rat liver endoplasmic reticulum protein, ERp29. Mkrtchian, S., Fang, C., Hellman, U., Ingelman-Sundberg, M. Eur. J. Biochem. (1998)
- ER calcium discharge stimulates GDNF gene expression through MAPK-dependent and -independent pathways in rat C6 glioblastoma cells. Oh-hashi, K., Kaneyama, M., Hirata, Y., Kiuchi, K. Neurosci. Lett. (2006)
- Detection of a serum DNA-binding protein associated with cancer. Galvan, L., Evans, J.E., Comis, R.L., Gottlieb, A., Gyorkey, F., Lane, M., Prestayko, A.W., Crooke, S.T. Cancer Res. (1982)
- RXRA and HSPA5 map to the telomeric end of dog chromosome 9. Werner, P., Raducha, M.G., Prociuk, U., Lyons, L.A., Kehler, J.S., Henthorn, P.S., Patterson, D.F. Anim. Genet. (1998)
- Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers. Baumeister, P., Luo, S., Skarnes, W.C., Sui, G., Seto, E., Shi, Y., Lee, A.S. Mol. Cell. Biol. (2005)
- Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Obeng, E.A., Carlson, L.M., Gutman, D.M., Harrington, W.J., Lee, K.P., Boise, L.H. Blood (2006)
- Transcriptional regulation of the Grp78 promoter by endoplasmic reticulum stress: role of TFII-I and its tyrosine phosphorylation. Hong, M., Lin, M.Y., Huang, J.M., Baumeister, P., Hakre, S., Roy, A.L., Lee, A.S. J. Biol. Chem. (2005)
- BiP binds type I procollagen pro alpha chains with mutations in the carboxyl-terminal propeptide synthesized by cells from patients with osteogenesis imperfecta. Chessler, S.D., Byers, P.H. J. Biol. Chem. (1993)
- Grp78 is involved in retention of mutant low density lipoprotein receptor protein in the endoplasmic reticulum. Jørgensen, M.M., Jensen, O.N., Holst, H.U., Hansen, J.J., Corydon, T.J., Bross, P., Bolund, L., Gregersen, N. J. Biol. Chem. (2000)
- Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress. Ma, K., Vattem, K.M., Wek, R.C. J. Biol. Chem. (2002)
- Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target for stress-induced phosphorylation. Luo, S., Lee, A.S. Biochem. J. (2002)
- Phage display derived human monoclonal antibodies isolated by binding to the surface of live primary breast cancer cells recognize GRP78. Jakobsen, C.G., Rasmussen, N., Laenkholm, A.V., Ditzel, H.J. Cancer Res. (2007)
- Involvement of endoplasmic reticulum chaperones in the folding of hepatitis C virus glycoproteins. Choukhi, A., Ung, S., Wychowski, C., Dubuisson, J. J. Virol. (1998)
- Association of glucose-regulated protein (grp78) with human keratin 8. Liao, J., Price, D., Omary, M.B. FEBS Lett. (1997)
- ER stress signaling by regulated proteolysis of ATF6. Shen, J., Prywes, R. Methods (2005)
- Down-regulation of epidermal growth factor receptor-signaling pathway by binding of GRP78/BiP to the receptor under glucose-starved stress conditions. Cai, B., Tomida, A., Mikami, K., Nagata, K., Tsuruo, T. J. Cell. Physiol. (1998)
- Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response. Shen, J., Snapp, E.L., Lippincott-Schwartz, J., Prywes, R. Mol. Cell. Biol. (2005)
- Induction of the mammalian GRP78/BiP gene by Ca2+ depletion and formation of aberrant proteins: activation of the conserved stress-inducible grp core promoter element by the human nuclear factor YY1. Li, W.W., Hsiung, Y., Zhou, Y., Roy, B., Lee, A.S. Mol. Cell. Biol. (1997)
- ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Ye, J., Rawson, R.B., Komuro, R., Chen, X., Davé, U.P., Prywes, R., Brown, M.S., Goldstein, J.L. Mol. Cell (2000)
- ATF6 modulates SREBP2-mediated lipogenesis. Zeng, L., Lu, M., Mori, K., Luo, S., Lee, A.S., Zhu, Y., Shyy, J.Y. EMBO J. (2004)
- The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters. McCauliffe, D.P., Yang, Y.S., Wilson, J., Sontheimer, R.D., Capra, J.D. J. Biol. Chem. (1992)
- The asparagine-linked oligosaccharides of the human chorionic gonadotropin beta subunit facilitate correct disulfide bond pairing. Feng, W., Matzuk, M.M., Mountjoy, K., Bedows, E., Ruddon, R.W., Boime, I. J. Biol. Chem. (1995)
- Role of extracellular molecular chaperones in the folding of oxidized proteins. Refolding of colloidal thyroglobulin by protein disulfide isomerase and immunoglobulin heavy chain-binding protein. Delom, F., Mallet, B., Carayon, P., Lejeune, P.J. J. Biol. Chem. (2001)
- Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis. Shuda, M., Kondoh, N., Imazeki, N., Tanaka, K., Okada, T., Mori, K., Hada, A., Arai, M., Wakatsuki, T., Matsubara, O., Yamamoto, N., Yamamoto, M. J. Hepatol. (2003)
- Selective cytotoxic activity of valinomycin against HT-29 Human colon carcinoma cells via down-regulation of GRP78. Ryoo, I.J., Park, H.R., Choo, S.J., Hwang, J.H., Park, Y.M., Bae, K.H., Shin-Ya, K., Yoo, I.D. Biol. Pharm. Bull. (2006)