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Gene Review

BUL1  -  ubiquitin-ubiquitin ligase BUL1

Saccharomyces cerevisiae S288c

Synonyms: DAG1, RDS1, Respiration deficiency suppressor 1, SMM2, Ubiquitin ligase-binding protein BUL1, ...
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High impact information on BUL1

  • A second mutation, smm2, which also suppressed mdm1-252 defects, but did not cause aberrant mitochondrial distribution and morphology, mapped to BUL1, encoding a protein interacting with Rsp5p [1].
  • Suppression of temperature sensitivity by an osmotic stabilizer is also observed in the bul1 bul2 double null mutant, and the temperature sensitivity of the bul1 bul2 double null mutant is suppressed by multiple copies of MCK1 [2].
  • We find that Rog1, but not Rog2, is stabilized in the gsk-3 null and the bul1 bul2 double null mutants [2].
  • Thus, we named our gene BUL1 (for a protein that binds to the ubiquitin ligase) [3].
  • Coexpression of RSP5 and BUL1 on a multicopy plasmid was toxic for mitotic growth of the wild-type cells [3].

Biological context of BUL1

  • We demonstrate here that heat shock element (HSE)-mediated gene expression was defective in both rsp5-101 and bul1 bul2 mutants under high temperature condition [4].
  • A chromosomal BUL1 deletion displayed all phenotypes shown by the PB-resistant mutant [5].

Associations of BUL1 with chemical compounds

  • Furthermore, both Bul1 and Rsp5 appeared to be associated with large complexes which were separated through a sucrose gradient centrifugation, and Rsp5 was coimmunoprecipitated with Bul1 [3].

Physical interactions of BUL1


Regulatory relationships of BUL1

  • Thus, NPR1 and BUL1/2 antagonistically control GLN3-dependent transcription, suggesting a role for regulated ubiquitination in the control of nutrient-responsive transcription [7].

Other interactions of BUL1


Analytical, diagnostic and therapeutic context of BUL1

  • Since the steady-state levels of the protein were the same in the two strains as determined by immunoblotting analysis, Bul1 might be easily degraded during immunoprecipitation in the absence of intact Rsp5 [3].


  1. A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae. Fisk, H.A., Yaffe, M.P. J. Cell Biol. (1999) [Pubmed]
  2. Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5. Andoh, T., Hirata, Y., Kikuchi, A. Mol. Cell. Biol. (2000) [Pubmed]
  3. Bul1, a new protein that binds to the Rsp5 ubiquitin ligase in Saccharomyces cerevisiae. Yashiroda, H., Oguchi, T., Yasuda, Y., Toh-E, A., Kikuchi, Y. Mol. Cell. Biol. (1996) [Pubmed]
  4. Rsp5-Bul1/2 complex is necessary for the HSE-mediated gene expression in budding yeast. Kaida, D., Toh-e, A., Kikuchi, Y. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  5. Immunosuppressant-like effects of phenylbutyrate on growth inhibition of Saccharomyces cerevisiae. Grzanowski, A., Needleman, R., Brusilow, W.S. Curr. Genet. (2002) [Pubmed]
  6. The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions. Yashiroda, H., Kaida, D., Toh-e, A., Kikuchi, Y. Gene (1998) [Pubmed]
  7. NPR1 kinase and RSP5-BUL1/2 ubiquitin ligase control GLN3-dependent transcription in Saccharomyces cerevisiae. Crespo, J.L., Helliwell, S.B., Wiederkehr, C., Demougin, P., Fowler, B., Primig, M., Hall, M.N. J. Biol. Chem. (2004) [Pubmed]
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