Gene Review:
MCK1 - Mck1p
Saccharomyces cerevisiae S288c
Synonyms:
CMS1, Meiosis and centromere regulatory kinase, N0392, Protein kinase MCK1, YNL307C, ...
- The yeast MCK1 gene encodes a protein kinase homolog that activates early meiotic gene expression. Neigeborn, L., Mitchell, A.P. Genes Dev. (1991)
- Mck1, a member of the glycogen synthase kinase 3 family of protein kinases, is a negative regulator of pyruvate kinase in the yeast Saccharomyces cerevisiae. Brazill, D.T., Thorner, J., Martin, G.S. J. Bacteriol. (1997)
- The Saccharomyces cerevisiae GSK-3beta homologs. Kassir, Y., Rubin-Bejerano, I., Mandel-Gutfreund, Y. Current drug targets (2006)
- Novel Saccharomyces cerevisiae gene, MRK1, encoding a putative protein kinase with similarity to mammalian glycogen synthase kinase-3 and Drosophila Zeste-White3/Shaggy. Hardy, T.A., Wu, D., Roach, P.J. Biochem. Biophys. Res. Commun. (1995)
- MDS1, a dosage suppressor of an mck1 mutant, encodes a putative yeast homolog of glycogen synthase kinase 3. Puziss, J.W., Hardy, T.A., Johnson, R.B., Roach, P.J., Hieter, P. Mol. Cell. Biol. (1994)
- Essential functions of protein tyrosine phosphatases PTP2 and PTP3 and RIM11 tyrosine phosphorylation in Saccharomyces cerevisiae meiosis and sporulation. Zhan, X.L., Hong, Y., Zhu, T., Mitchell, A.P., Deschenes, R.J., Guan, K.L. Mol. Biol. Cell (2000)
- Roles of trehalose phosphate synthase in yeast glycogen metabolism and sporulation. De Silva-Udawatta, M.N., Cannon, J.F. Mol. Microbiol. (2001)
- Overexpression of the yeast MCK1 protein kinase suppresses conditional mutations in centromere-binding protein genes CBF2 and CBF5. Jiang, W., Lim, M.Y., Yoon, H.J., Thorner, J., Martin, G.S., Carbon, J. Mol. Gen. Genet. (1995)
- Monitoring active site alterations upon mutation of yeast pyruvate kinase using 205Tl+ NMR. Susan-Resiga, D., Nowak, T. J. Biol. Chem. (2003)
- GSK-3 kinase Mck1 and calcineurin coordinately mediate Hsl1 down-regulation by Ca2+ in budding yeast. Mizunuma, M., Hirata, D., Miyaoka, R., Miyakawa, T. EMBO J. (2001)
- Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5. Andoh, T., Hirata, Y., Kikuchi, A. Mol. Cell. Biol. (2000)
- Direct and novel regulation of cAMP-dependent protein kinase by Mck1p, a yeast glycogen synthase kinase-3. Rayner, T.F., Gray, J.V., Thorner, J.W. J. Biol. Chem. (2002)
- The dual-specificity protein phosphatase Yvh1p acts upstream of the protein kinase mck1p in promoting spore development in Saccharomyces cerevisiae. Beeser, A.E., Cooper, T.G. J. Bacteriol. (1999)
- Molecular characterization of the yeast meiotic regulatory gene RIM1. Su, S.S., Mitchell, A.P. Nucleic Acids Res. (1993)
- The Kluyveromyces lactis gene KLGSK-3 combines functions which in Saccharomyces cerevisiae are performed by MCK1 and MSD1. Rodríguez-Belmonte, E., González-Siso, I., Cerdán, E. Curr. Genet. (1998)
- Yeast MCK1 protein kinase autophosphorylates at tyrosine and serine but phosphorylates exogenous substrates at serine and threonine. Lim, M.Y., Dailey, D., Martin, G.S., Thorner, J. J. Biol. Chem. (1993)
- Role of lysine 240 in the mechanism of yeast pyruvate kinase catalysis. Bollenbach, T.J., Mesecar, A.D., Nowak, T. Biochemistry (1999)