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Gene Review

ORC5  -  origin recognition complex subunit 5

Saccharomyces cerevisiae S288c

Synonyms: N0834, Origin recognition complex 53 kDa subunit, Origin recognition complex subunit 5, YNL261W
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High impact information on ORC5

  • The sequence of ORC5 revealed a potential ATP binding site, making Orc5p a candidate for a subunit that mediates the ATP-dependent binding of ORC to origins [1].
  • To study the function of the ORC during defined cell cycle periods, we performed cell cycle execution point analyses with strains containing a conditional mutation in the ORC1, ORC2 or ORC5 subunit of ORC [2].
  • The conservation of structure among members of the ORC4- and ORC5-related family of proteins suggests that these proteins play a key role in the initiation of DNA replication in all eukaryotes [3].
  • We have determined the nucleotide sequence of a chromosomal region of 33,016 bp located on the left arm of chromosome XIV from budding yeast between the ORC5 and the SUI1 gene [4].

Analytical, diagnostic and therapeutic context of ORC5


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