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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ORC5  -  origin recognition complex subunit 5

Saccharomyces cerevisiae S288c

Synonyms: N0834, Origin recognition complex 53 kDa subunit, Origin recognition complex subunit 5, YNL261W
 
 
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High impact information on ORC5

  • The sequence of ORC5 revealed a potential ATP binding site, making Orc5p a candidate for a subunit that mediates the ATP-dependent binding of ORC to origins [1].
  • To study the function of the ORC during defined cell cycle periods, we performed cell cycle execution point analyses with strains containing a conditional mutation in the ORC1, ORC2 or ORC5 subunit of ORC [2].
  • The conservation of structure among members of the ORC4- and ORC5-related family of proteins suggests that these proteins play a key role in the initiation of DNA replication in all eukaryotes [3].
  • We have determined the nucleotide sequence of a chromosomal region of 33,016 bp located on the left arm of chromosome XIV from budding yeast between the ORC5 and the SUI1 gene [4].
 

Analytical, diagnostic and therapeutic context of ORC5

References

  1. The origin recognition complex in silencing, cell cycle progression, and DNA replication. Loo, S., Fox, C.A., Rine, J., Kobayashi, R., Stillman, B., Bell, S. Mol. Biol. Cell (1995) [Pubmed]
  2. Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae. Gibson, D.G., Bell, S.P., Aparicio, O.M. Genes Cells (2006) [Pubmed]
  3. Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex. Springer, J., Kneissl, M., Pütter, V., Grummt, F. Chromosoma (1999) [Pubmed]
  4. Sequence analysis of the 33 kb long region between ORC5 and SUI1 from the left arm of chromosome XIV from Saccharomyces cerevisiae. Sen-Gupta, M., Güldener, U., Beinhauer, J., Fiedler, T., Hegemann, J.H. Yeast (1997) [Pubmed]
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