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Gene Review

PDR16  -  Pdr16p

Saccharomyces cerevisiae S288c

Synonyms: N1158, PITP, Phosphatidylinositol transfer protein PDR16, Pleiotropic drug resistance protein 16, SEC14 homolog 3, ...
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Disease relevance of PDR16


High impact information on PDR16


Biological context of PDR16

  • Our results show that the homozygous pdr16Delta/pdr16Delta mutant is approximately twofold less resistant to azoles than the parental strain whereas reintroducing a copy of PDR16 in the mutant restored azole resistance, demonstrating that this gene contributes to the AR phenotype of the cells [2].

Anatomical context of PDR16


  1. PDR16 and PDR17, two homologous genes of Saccharomyces cerevisiae, affect lipid biosynthesis and resistance to multiple drugs. van den Hazel, H.B., Pichler, H., do Valle Matta, M.A., Leitner, E., Goffeau, A., Daum, G. J. Biol. Chem. (1999) [Pubmed]
  2. PDR16-mediated azole resistance in Candida albicans. Saidane, S., Weber, S., De Deken, X., St-Germain, G., Raymond, M. Mol. Microbiol. (2006) [Pubmed]
  3. Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover. Schnabl, M., Oskolkova, O.V., Holic, R., Brezná, B., Pichler, H., Zágorsek, M., Kohlwein, S.D., Paltauf, F., Daum, G., Griac, P. Eur. J. Biochem. (2003) [Pubmed]
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