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Chemical Compound Review

mycophenolic acid     (E)-6-(4-hydroxy-6-methoxy-7- methyl-3-oxo...

Synonyms: Myfortic, Melbex, Mycophenolate, UPCMLD-DP028, Prestwick_817, ...
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Disease relevance of mycophenolic acid


Psychiatry related information on mycophenolic acid


High impact information on mycophenolic acid


Chemical compound and disease context of mycophenolic acid


Biological context of mycophenolic acid


Anatomical context of mycophenolic acid


Associations of mycophenolic acid with other chemical compounds


Gene context of mycophenolic acid


Analytical, diagnostic and therapeutic context of mycophenolic acid


  1. Effects of mycophenolic acid on human immunodeficiency virus infection in vitro and in vivo. Chapuis, A.G., Paolo Rizzardi, G., D'Agostino, C., Attinger, A., Knabenhans, C., Fleury, S., Acha-Orbea, H., Pantaleo, G. Nat. Med. (2000) [Pubmed]
  2. Mycophenolic Acid Inhibits Hepatitis C Virus Replication and Acts in Synergy With Cyclosporin A and Interferon-alpha. Henry, S.D., Metselaar, H.J., Lonsdale, R.C., Kok, A., Haagmans, B.L., Tilanus, H.W., van der Laan, L.J. Gastroenterology (2006) [Pubmed]
  3. Pharmacodynamics of mycophenolate mofetil after nonmyeloablative conditioning and unrelated donor hematopoietic cell transplantation. Giaccone, L., McCune, J.S., Maris, M.B., Gooley, T.A., Sandmaier, B.M., Slattery, J.T., Cole, S., Nash, R.A., Storb, R.F., Georges, G.E. Blood (2005) [Pubmed]
  4. Biological effects of inhibition of guanine nucleotide synthesis by mycophenolic acid in cultured neuroblastoma cells. Cass, C.E., Lowe, J.K., Manchak, J.M., Henderson, J.F. Cancer Res. (1977) [Pubmed]
  5. Pharmacokinetics of intravenous mycophenolate mofetil after allogeneic blood stem cell transplantation. Jenke, A., Renner, U., Richte, M., Freiberg-Richter, J., Platzbecker, U., Helwig, A., Thiede, H.M., Schäfer-Eckart, K., Ehninger, G., Bornhäuser, M. Clinical transplantation. (2001) [Pubmed]
  6. Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid. Sintchak, M.D., Fleming, M.A., Futer, O., Raybuck, S.A., Chambers, S.P., Caron, P.R., Murcko, M.A., Wilson, K.P. Cell (1996) [Pubmed]
  7. Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo. Mason, P.B., Struhl, K. Mol. Cell (2005) [Pubmed]
  8. Human hand allograft: report on first 6 months. Dubernard, J.M., Owen, E., Herzberg, G., Lanzetta, M., Martin, X., Kapila, H., Dawahra, M., Hakim, N.S. Lancet (1999) [Pubmed]
  9. Integration of Ecogpt and SV40 early region sequences into human chromosome 17: a dominant selection system in whole cell and microcell human-mouse hybrids. Tunnacliffe, A., Parkar, M., Povey, S., Bengtsson, B.O., Stanley, K., Solomon, E., Goodfellow, P. EMBO J. (1983) [Pubmed]
  10. Guanine nucleotide depletion and toxicity in mouse T lymphoma (S-49) cells. Cohen, M.B., Maybaum, J., Sadee, W. J. Biol. Chem. (1981) [Pubmed]
  11. The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase. Leyssen, P., Balzarini, J., De Clercq, E., Neyts, J. J. Virol. (2005) [Pubmed]
  12. Effects of the inhibitors of IMP dehydrogenase, tiazofurin and mycophenolic acid, on glycoprotein metabolism. Sokoloski, J.A., Sartorelli, A.C. Mol. Pharmacol. (1985) [Pubmed]
  13. Enteric-coated mycophenolate sodium: tolerability profile compared with mycophenolate mofetil. Behrend, M., Braun, F. Drugs (2005) [Pubmed]
  14. A cell line that supports the growth of a defective early region 4 deletion mutant of human adenovirus type 2. Weinberg, D.H., Ketner, G. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  15. Detection of the mycophenolate-inhibited form of IMP dehydrogenase in vivo. McPhillips, C.C., Hyle, J.W., Reines, D. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  16. Induction of apoptosis in IL-3-dependent hematopoietic cell lines by guanine nucleotide depletion. Gu, J.J., Gathy, K., Santiago, L., Chen, E., Huang, M., Graves, L.M., Mitchell, B.S. Blood (2003) [Pubmed]
  17. Gene transfer from targeted liposomes to specific lymphoid cells by electroporation. Machy, P., Lewis, F., McMillan, L., Jonak, Z.L. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  18. A tumor necrosis factor-responsive long-term-culture-initiating cell is associated with the stromal layer of mouse long-term bone marrow cultures. Rogers, J.A., Berman, J.W. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  19. Expression of IMP dehydrogenase in differentiating HL-60 cells. Collart, F.R., Huberman, E. Blood (1990) [Pubmed]
  20. DNA-mediated transfer and expression of a human DNA repair gene that demethylates O6-methylguanine. Ding, R., Ghosh, K., Eastman, A., Bresnick, E. Mol. Cell. Biol. (1985) [Pubmed]
  21. Effects of mycophenolic acid on detection of glial filaments in human and rat astrocytoma cultures. Lipsky, R.H., Silverman, S.J. Cancer Res. (1987) [Pubmed]
  22. Differentiation of human prostate cancer PC-3 cells induced by inhibitors of inosine 5'-monophosphate dehydrogenase. Floryk, D., Tollaksen, S.L., Giometti, C.S., Huberman, E. Cancer Res. (2004) [Pubmed]
  23. p53-independent induction of p21(waf1/cip1) contributes to the activation of caspases in GTP-depletion-induced apoptosis of insulin-secreting cells. Huo, J.X., Metz, S.A., Li, G.D. Cell Death Differ. (2004) [Pubmed]
  24. Effects of tiazofurin on protooncogene expression during HL-60 cell differentiation. Kharbanda, S.M., Sherman, M.L., Spriggs, D.R., Kufe, D.W. Cancer Res. (1988) [Pubmed]
  25. Regulation of the interaction of inosine monophosphate dehydrogenase with mycophenolic Acid by GTP. Ji, Y., Gu, J., Makhov, A.M., Griffith, J.D., Mitchell, B.S. J. Biol. Chem. (2006) [Pubmed]
  26. Screening the yeast "disruptome" for mutants affecting resistance to the immunosuppressive drug, mycophenolic acid. Desmoucelles, C., Pinson, B., Saint-Marc, C., Daignan-Fornier, B. J. Biol. Chem. (2002) [Pubmed]
  27. Synthetic lethal interactions suggest a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation. Costa, P.J., Arndt, K.M. Genetics (2000) [Pubmed]
  28. Dissection of the molecular basis of mycophenolate resistance in Saccharomyces cerevisiae. Jenks, M.H., Reines, D. Yeast (2005) [Pubmed]
  29. The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid. Mojarrabi, B., Mackenzie, P.I. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  30. Identification of uridine diphosphate glucuronosyltransferases involved in the metabolism and clearance of mycophenolic acid. Mackenzie, P.I. Therapeutic drug monitoring. (2000) [Pubmed]
  31. Amplification of the IMP dehydrogenase gene in Chinese hamster cells resistant to mycophenolic acid. Collart, F.R., Huberman, E. Mol. Cell. Biol. (1987) [Pubmed]
  32. The functional basis of mycophenolic acid resistance in Candida albicans IMP dehydrogenase. Köhler, G.A., Gong, X., Bentink, S., Theiss, S., Pagani, G.M., Agabian, N., Hedstrom, L. J. Biol. Chem. (2005) [Pubmed]
  33. Explaining variability in mycophenolic acid exposure to optimize mycophenolate mofetil dosing: a population pharmacokinetic meta-analysis of mycophenolic acid in renal transplant recipients. van Hest, R.M., Mathot, R.A., Pescovitz, M.D., Gordon, R., Mamelok, R.D., van Gelder, T. J. Am. Soc. Nephrol. (2006) [Pubmed]
  34. Pharmacokinetics of mycophenolate mofetil in patients with autoimmune diseases compared renal transplant recipients. Neumann, I., Haidinger, M., Jäger, H., Grützmacher, H., Griesmacher, A., Müller, M.M., Bayer, P.M., Meisl, F.T. J. Am. Soc. Nephrol. (2003) [Pubmed]
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